{"id":"ibandronate-iv","safety":{"commonSideEffects":[{"rate":null,"effect":"Osteonecrosis of the jaw"},{"rate":null,"effect":"Atypical femoral fractures"},{"rate":null,"effect":"Musculoskeletal pain"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Renal impairment"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As a nitrogen-containing bisphosphonate, ibandronate accumulates in bone and is taken up by osteoclasts during bone resorption. It inhibits farnesyl pyrophosphate synthase, disrupting the prenylation of small GTPases essential for osteoclast function, leading to osteoclast apoptosis and reduced bone turnover. This mechanism makes it effective for conditions characterized by excessive bone loss.","oneSentence":"Ibandronate is a bisphosphonate that inhibits osteoclast-mediated bone resorption by binding to hydroxyapatite in bone and blocking farnesyl pyrophosphate synthase in the mevalonate pathway.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:47:58.811Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Osteoporosis in postmenopausal women"},{"name":"Bone metastases and hypercalcemia of malignancy"},{"name":"Paget's disease of bone"}]},"trialDetails":[{"nctId":"NCT07406685","phase":"PHASE4","title":"The Comparison of Ibandronate and Zoledronic Acid After Denosumab Discontinuation","status":"NOT_YET_RECRUITING","sponsor":"National Taiwan University Hospital","startDate":"2026-03-17","conditions":"Postmenopausal Osteoporosis, Postmenopausal Osteopenia, Primary Osteoporosis","enrollment":52},{"nctId":"NCT07043608","phase":"PHASE2","title":"Zanzalintinib for Metastatic Clear Cell Renal Cell Carcinoma With Bone Metastases","status":"NOT_YET_RECRUITING","sponsor":"Kelly Fitzgerald, MD","startDate":"2025-09-30","conditions":"Clear Cell Renal Cell Cancer (ccRCC), Clear Cell Renal Carcinoma, Clear Cell Renal Cell Carcinoma Metastatic","enrollment":20},{"nctId":"NCT02520362","phase":"","title":"Denosumab Safety Assessment in Multiple Observational Databases","status":"COMPLETED","sponsor":"Amgen","startDate":"2010-05-31","conditions":"Osteoporosis","enrollment":517991},{"nctId":"NCT00127205","phase":"PHASE3","title":"S0307 Phase III Trial of Bisphosphonates as Adjuvant Therapy for Primary Breast Cancer.","status":"COMPLETED","sponsor":"SWOG Cancer Research Network","startDate":"2005-07","conditions":"Breast Cancer","enrollment":6097},{"nctId":"NCT00099203","phase":"PHASE3","title":"A Study to Assess the Efficacy of Intravenous Bondronat (Ibandronate) in Patients With Malignant and Painful Bone Disease","status":"TERMINATED","sponsor":"Hoffmann-La Roche","startDate":"2005-07","conditions":"Pain, Bone Neoplasm, Neoplasm Metastasis","enrollment":163},{"nctId":"NCT00478270","phase":"PHASE2","title":"A Study of Loading Doses of Intravenous Bondronat (Ibandronate) in Patients With Breast Cancer and Metastatic Bone Disease.","status":"WITHDRAWN","sponsor":"Hoffmann-La Roche","startDate":"2007-06","conditions":"Pain, Bone Neoplasm, Neoplasm Metastasis","enrollment":""},{"nctId":"NCT00099177","phase":"PHASE3","title":"A Study to Assess the Efficacy of Intravenous/Oral Bondronat (Ibandronate) in Patients With Metastatic Bone Disease Experiencing Moderate to Severe Pain","status":"TERMINATED","sponsor":"Hoffmann-La Roche","startDate":"2005-08","conditions":"Pain, Bone Neoplasm, Neoplasm Metastasis","enrollment":96},{"nctId":"NCT02114489","phase":"PHASE3","title":"Study Comparing Ibandronate Versus Placebo in Hip Osteonecrosis","status":"TERMINATED","sponsor":"Brigitte Jolles, MD","startDate":"2014-06","conditions":"Aseptic Hip Necrosis, Hip Necrosis","enrollment":8},{"nctId":"NCT02598453","phase":"PHASE4","title":"PRIOR Study - A Study of Ibandronate (Boniva) in Postmenopausal Women With Osteoporosis or Osteopenia","status":"COMPLETED","sponsor":"Hoffmann-La Roche","startDate":"2005-01","conditions":"Postmenopausal Osteoporosis","enrollment":545},{"nctId":"NCT01128257","phase":"","title":"A Study of Ibandronate [Bonviva/Boniva] and Alendronate in Female Patients With Post-Menopausal Osteoporosis","status":"COMPLETED","sponsor":"Hoffmann-La Roche","startDate":"2010-04","conditions":"Postmenopausal Osteoporosis","enrollment":6054},{"nctId":"NCT00493532","phase":"","title":"A Study of Quarterly Intravenous Bonviva (Ibandronate) in Women With Post-Menopausal Osteoporosis.","status":"NO_LONGER_AVAILABLE","sponsor":"Hoffmann-La Roche","startDate":"2007-06","conditions":"Postmenopausal Osteoporosis","enrollment":""},{"nctId":"NCT02561039","phase":"PHASE3","title":"A Study of Ibandronate (Bondronat) in Participants With Malignant Bone Disease","status":"COMPLETED","sponsor":"Hoffmann-La Roche","startDate":"2006-12","conditions":"Pain; Bone Neoplasms; Neoplasm Metastasis","enrollment":97},{"nctId":"NCT02739594","phase":"PHASE3","title":"Comparison of Ibandronate - Zoledronate Regarding Nephrotoxicity in Multiple Myeloma","status":"TERMINATED","sponsor":"Hoffmann-La Roche","startDate":"2006-02","conditions":"Multiple Myeloma","enrollment":89},{"nctId":"NCT02716792","phase":"PHASE3","title":"A Study to Evaluate Renal Safety of Intravenous Ibandronate (Bondronat) in Participants With Metastatic Bone Disease Due to Breast Cancer","status":"COMPLETED","sponsor":"Hoffmann-La Roche","startDate":"2006-01","conditions":"Pain; Bone Neoplasms; Neoplasm Metastasis","enrollment":334},{"nctId":"NCT00048074","phase":"PHASE3","title":"DIVA Study - A Study of Different Regimens of Intravenous Administration of Bonviva (Ibandronate) in Women With Post-Menopausal Osteoporosis","status":"COMPLETED","sponsor":"Hoffmann-La Roche","startDate":"2002-06","conditions":"Post Menopausal Osteoporosis","enrollment":1395},{"nctId":"NCT02553707","phase":"PHASE4","title":"A Study to Assess the Short Term Efficacy of Intravenous Ibandronate (Bondronat) in Participants With Metastatic Bone Pain Due to Breast Cancer","status":"COMPLETED","sponsor":"Hoffmann-La Roche","startDate":"2006-07","conditions":"Pain; 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Used for Osteoporosis in postmenopausal women, Bone metastases and hypercalcemia of malignancy, Paget's disease of bone.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}