{"id":"i-v-iron-sucrose","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Diarrhea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Iron sucrose consists of iron(III) hydroxide bonded to sucrose, forming a stable complex that can be administered intravenously without the tissue toxicity associated with free iron. Once in circulation, the iron is transferred to transferrin and other iron-binding proteins for transport to bone marrow and other tissues, where it is incorporated into hemoglobin and other iron-dependent proteins. This mechanism bypasses gastrointestinal absorption limitations and is particularly useful in patients with chronic kidney disease who cannot tolerate or absorb oral iron adequately.","oneSentence":"Iron sucrose is a stable iron-carbohydrate complex that delivers iron directly into the bloodstream to replenish depleted iron stores and support hemoglobin synthesis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:33:12.651Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Iron deficiency anemia in patients with chronic kidney disease on hemodialysis"},{"name":"Iron deficiency anemia in patients with chronic kidney disease not on dialysis"},{"name":"Iron deficiency anemia in patients with non-dialysis-dependent chronic kidney disease"}]},"trialDetails":[{"nctId":"NCT02441439","phase":"NA","title":"To Compare the Efficacy of I.V 200 mg Iron Sucrose and 500 mg Iron Sucrose to Treat Anemia in Pregnancy","status":"WITHDRAWN","sponsor":"HaEmek Medical Center, Israel","startDate":"2022-01-01","conditions":"Pregnancy","enrollment":""},{"nctId":"NCT05151679","phase":"","title":"Chelated Oral Iron Versus Intravenous Iron Sucrose for Treatment of Iron Deficiency Anemia Late in Pregnancy","status":"AVAILABLE","sponsor":"Assiut University","startDate":"","conditions":"Iron Deficiency Anemia of Pregnancy","enrollment":""},{"nctId":"NCT02458625","phase":"NA","title":"A Comparison Between Intravenous Iron Sucrose to Its Combination With Oral Iron Supplements for the Treatment of Postpartum Anemia","status":"COMPLETED","sponsor":"HaEmek Medical Center, Israel","startDate":"2016-04","conditions":"Postpartum Anemia","enrollment":158},{"nctId":"NCT04225728","phase":"PHASE4","title":"Evaluation on Performance and Oxydative Stress in Patient With Iron deficIency and Stable Heart Failure Study","status":"COMPLETED","sponsor":"CN NGANOU-GNINDJIO, MD, MSc","startDate":"2017-12-01","conditions":"Chronic Heart Failure (CHF), Iron Deficiency","enrollment":45},{"nctId":"NCT02392910","phase":"PHASE4","title":"Hospitalization & Mortality in Patients With Iron Deficiency CKD and HF Treated With i.v. Iron.","status":"COMPLETED","sponsor":"Hospital Aleman","startDate":"2006-03","conditions":"Iron Deficiency, Heart Failure, Chronic Kidney Disease","enrollment":40},{"nctId":"NCT00810030","phase":"PHASE3","title":"FERINJECT for Correction of Anaemia in IBD Patients, FER-IBD-COR","status":"COMPLETED","sponsor":"Vifor Pharma","startDate":"2008-10","conditions":"Inflammatory Bowel Disease, Anemia, Iron Deficiency","enrollment":484},{"nctId":"NCT00557817","phase":"PHASE2, PHASE3","title":"Erythropoietin (Epo) and Venofer Trial After Autologous Hematopoietic Stem Cell Transplantation (HSCT)","status":"COMPLETED","sponsor":"University of Liege","startDate":"2004-03","conditions":"Hematological Malignancies","enrollment":125},{"nctId":"NCT00145652","phase":"PHASE3","title":"Adjuvant I.V. Iron Therapy During Erythropoetin Treatment of Anemic Patients With Lymphoproliferative Disorders.","status":"COMPLETED","sponsor":"Sundsvall Hospital","startDate":"2003-12","conditions":"Anemia, Multiple Myeloma, Non Hodgkin Lymphoma","enrollment":66},{"nctId":"NCT00199277","phase":"PHASE4","title":"Iron Therapy in Colo-Rectal Neoplasm and Iron Deficiency Anemia: Intravenous Iron Sucrose Versus Oral Ferrous Sulphate.","status":"UNKNOWN","sponsor":"J. Uriach and Company","startDate":"","conditions":"Colorectal Neoplasm, Iron Deficiency Anemia","enrollment":150}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"i.v. iron sucrose","genericName":"i.v. iron sucrose","companyName":"J. Uriach and Company","companyId":"j-uriach-and-company","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Iron sucrose is a stable iron-carbohydrate complex that delivers iron directly into the bloodstream to replenish depleted iron stores and support hemoglobin synthesis. Used for Iron deficiency anemia in patients with chronic kidney disease on hemodialysis, Iron deficiency anemia in patients with chronic kidney disease not on dialysis, Iron deficiency anemia in patients with non-dialysis-dependent chronic kidney disease.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}