{"id":"i-v-ampicillin-2-gram-x4-d-for-2-days","safety":{"commonSideEffects":[{"rate":"5-10","effect":"Diarrhea"},{"rate":"2-5","effect":"Nausea"},{"rate":"1-3","effect":"Rash"},{"rate":"0.1-1","effect":"Allergic reaction / anaphylaxis"},{"rate":"1-3","effect":"Vomiting"},{"rate":"1-3","effect":"Abdominal pain"}]},"_chembl":{"chemblId":"CHEMBL174","moleculeType":"Small molecule","molecularWeight":"349.41"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ampicillin is a beta-lactam antibiotic that irreversibly inhibits transpeptidase enzymes responsible for cross-linking peptidoglycan strands in the bacterial cell wall. This disruption of cell wall integrity leads to bacterial cell lysis and death. It is bactericidal and effective against a broad spectrum of gram-positive and some gram-negative bacteria.","oneSentence":"Ampicillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins and blocking peptidoglycan cross-linking.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:47:48.539Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bacterial infections susceptible to ampicillin (e.g., respiratory tract infections, urinary tract infections, meningitis, endocarditis)"},{"name":"Gram-positive and some gram-negative bacterial infections"}]},"trialDetails":[{"nctId":"NCT02819570","phase":"PHASE4","title":"Comparison of Two Antibiotic Prophylactic Protocols in Preterm Premature Rupture of the Membranes","status":"UNKNOWN","sponsor":"Western Galilee Hospital-Nahariya","startDate":"2015-11","conditions":"Premature Rupture of Membrane","enrollment":400}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"I.V ampicillin 2 gram x4/d for 2 days","genericName":"I.V ampicillin 2 gram x4/d for 2 days","companyName":"Western Galilee Hospital-Nahariya","companyId":"western-galilee-hospital-nahariya","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ampicillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins and blocking peptidoglycan cross-linking. Used for Bacterial infections susceptible to ampicillin (e.g., respiratory tract infections, urinary tract infections, meningitis, endocarditis), Gram-positive and some gram-negative bacterial infections.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}