{"id":"i-m-injection-of-vitamin-b12","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain or erythema"},{"rate":null,"effect":"Hypokalemia (rare, with rapid correction)"},{"rate":null,"effect":"Allergic reaction (very rare)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Vitamin B12 is an essential water-soluble vitamin required for proper red blood cell formation, neurological function, and DNA synthesis. It serves as a cofactor for methionine synthase and methylmalonyl-CoA mutase, enzymes critical for homocysteine metabolism and fatty acid oxidation. Intramuscular injection bypasses gastrointestinal absorption issues, delivering B12 directly into systemic circulation for patients with deficiency due to pernicious anemia, malabsorption, or dietary insufficiency.","oneSentence":"Vitamin B12 (cobalamin) acts as a cofactor for enzymes involved in DNA synthesis, myelin formation, and energy metabolism.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:47:57.915Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Vitamin B12 deficiency anemia (pernicious anemia, malabsorption)"},{"name":"B12 deficiency-related neuropathy and neurological complications"},{"name":"Post-gastrectomy or ileal disease-related B12 deficiency"}]},"trialDetails":[{"nctId":"NCT01832129","phase":"PHASE4","title":"Vitamin B12 Acceptance and Biomarker Response Study","status":"COMPLETED","sponsor":"University Hospital, Basel, Switzerland","startDate":"2013-05","conditions":"Vitamin B 12 Deficiency","enrollment":37}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Vitamin B12 intramuscular","Cyanocobolamin","Vitarubin Depot"],"phase":"marketed","status":"active","brandName":"i.m. injection of vitamin B12","genericName":"i.m. injection of vitamin B12","companyName":"University Hospital, Basel, Switzerland","companyId":"university-hospital-basel-switzerland","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Vitamin B12 (cobalamin) acts as a cofactor for enzymes involved in DNA synthesis, myelin formation, and energy metabolism. Used for Vitamin B12 deficiency anemia (pernicious anemia, malabsorption), B12 deficiency-related neuropathy and neurological complications, Post-gastrectomy or ileal disease-related B12 deficiency.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}