{"id":"i-131-iodocholesterol","safety":{"commonSideEffects":[{"rate":null,"effect":"Radiation-related bone marrow suppression"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Fatigue"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This radiopharmaceutical combines iodine-131, a beta-emitting radionuclide, with iodocholesterol, a cholesterol derivative that preferentially accumulates in adrenocortical cells due to their high cholesterol uptake and metabolism. The localized radiation delivery enables both diagnostic imaging of adrenocortical lesions and therapeutic destruction of adrenocortical cancer cells. This approach exploits the unique metabolic characteristics of adrenocortical tissue to achieve selective targeting.","oneSentence":"I-131 Iodocholesterol is a radiolabeled cholesterol analog that localizes to adrenocortical tissue and delivers targeted radiation for imaging and therapeutic purposes in adrenocortical carcinoma.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:15:26.398Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Adrenocortical carcinoma (diagnostic and therapeutic)"}]},"trialDetails":[{"nctId":"NCT00037843","phase":"PHASE3","title":"Iodine I-131 Iodocholesterol, Its Use in Adrenal Screening","status":"COMPLETED","sponsor":"M.D. Anderson Cancer Center","startDate":"1988-12","conditions":"Adrenal Gland Diseases, Adrenal Gland Neoplasms","enrollment":114}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"I-131 Iodocholesterol","genericName":"I-131 Iodocholesterol","companyName":"M.D. Anderson Cancer Center","companyId":"m-d-anderson-cancer-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"I-131 Iodocholesterol is a radiolabeled cholesterol analog that localizes to adrenocortical tissue and delivers targeted radiation for imaging and therapeutic purposes in adrenocortical carcinoma. Used for Adrenocortical carcinoma (diagnostic and therapeutic).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}