{"id":"hyruan-plus","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain or swelling"},{"rate":null,"effect":"Transient joint effusion"},{"rate":null,"effect":"Local inflammation"}]},"_chembl":{"chemblId":"CHEMBL5314376","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The drug is a viscosupplement containing hyaluronic acid, a naturally occurring polysaccharide found in synovial fluid. It works by restoring the viscoelastic properties of joint fluid, reducing friction between cartilage surfaces and providing shock absorption. This helps alleviate pain and improve joint mobility in osteoarthritis.","oneSentence":"Hyruan Plus is a viscoelastic hyaluronic acid-based injection that provides lubrication and cushioning to damaged joints.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:15:17.856Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Osteoarthritis of the knee"}]},"trialDetails":[{"nctId":"NCT03484091","phase":"PHASE4","title":"Comparison of Single Intra-articular Injection of Hyruan-One With Hylan G-F 20 in Knee Osteoarthritis","status":"COMPLETED","sponsor":"Thammasat University","startDate":"2018-04-01","conditions":"Knee Osteoarthritis","enrollment":276},{"nctId":"NCT06437054","phase":"PHASE1, PHASE2","title":"Verification of the Efficacy/Safety of the Mixed Drug Injectable Delivery Vehicle for Treating Intractable Hearing Loss","status":"NOT_YET_RECRUITING","sponsor":"Seoul National University Hospital","startDate":"2025-09-15","conditions":"Hearing Loss, Sensorineural, Hearing Loss, Sudden, Intratympanic Injection","enrollment":26},{"nctId":"NCT05861570","phase":"NA","title":"Is Combined Steroid and Sodium Hyaluronate Hydrodilatation More Effective Than Isolated Steroid Hydrodilatation in Treating Patients With Adhesive Capsulitis","status":"UNKNOWN","sponsor":"Taipei Veterans General Hospital, Taiwan","startDate":"2023-05-18","conditions":"Adhesive Capsulitis","enrollment":84},{"nctId":"NCT02708706","phase":"NA","title":"The Efficacy of Ultrasound-guided Hydrodilatation With Hyaluronic Acid for Patients With Adhesive Capsulitis","status":"COMPLETED","sponsor":"Taipei Veterans General Hospital, Taiwan","startDate":"2016-03","conditions":"Adhesive Capsulitis","enrollment":62},{"nctId":"NCT05220527","phase":"PHASE4","title":"Effects of Knee Injections on Patients With Knee Osteoarthritis","status":"UNKNOWN","sponsor":"Taipei Medical University","startDate":"2020-08-01","conditions":"Knee Osteoarthritis, Injection, Effect of Drug","enrollment":60},{"nctId":"NCT02554240","phase":"PHASE2","title":"Study to Evaluate the Efficacy and Safety of Intra-articular DA-5202 in Patients With Osteoarthritis of the Knee","status":"COMPLETED","sponsor":"Dong-A ST Co., Ltd.","startDate":"2014-12-23","conditions":"Osteoarthritis, Knee","enrollment":115},{"nctId":"NCT03690232","phase":"NA","title":"Intraarticular Glucose Versus Hyaluronic Acid Injection for Knee Osteoarthrosis","status":"UNKNOWN","sponsor":"Taipei Veterans General Hospital, Taiwan","startDate":"2018-10-08","conditions":"Osteoarthritis, Knee","enrollment":100},{"nctId":"NCT03677895","phase":"NA","title":"What Factors Are Associated With Prognosis of Rotator Cuff Disorder After Subacromial Hyaluronic Acid Injection","status":"UNKNOWN","sponsor":"Taipei Veterans General Hospital, Taiwan","startDate":"2018-10-08","conditions":"Rotator Cuff Impingement Syndrome","enrollment":200},{"nctId":"NCT03548662","phase":"PHASE1","title":"The Effect of Platelet Rich Plasma Injection Combined With Exercise Rehabilitation in Patients With Rotator Cuff Tear","status":"COMPLETED","sponsor":"Taipei Veterans General Hospital, Taiwan","startDate":"2014-03-04","conditions":"Rotator Cuff Tear","enrollment":30},{"nctId":"NCT01510535","phase":"PHASE3","title":"Efficacy and Safety of LBSA0103 Versus Hyruan Plus Injection in Patients With Knee Osteoarthritis","status":"COMPLETED","sponsor":"LG Life Sciences","startDate":"2011-12","conditions":"Osteoarthritis of the Knee","enrollment":287}],"_emaApprovals":[],"_faersSignals":[{"count":1,"reaction":"MULTI-ORGAN FAILURE"}],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Hyruan Plus","genericName":"Hyruan Plus","companyName":"LG Life Sciences","companyId":"lg-life-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Hyruan Plus is a viscoelastic hyaluronic acid-based injection that provides lubrication and cushioning to damaged joints. Used for Osteoarthritis of the knee.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}