{"id":"hypotonic-hydration","safety":{"commonSideEffects":[{"rate":null,"effect":"Hyponatremia (if overcorrected)"},{"rate":null,"effect":"Cerebral edema (if correction too rapid)"},{"rate":null,"effect":"Phlebitis at infusion site"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Hypotonic hydration involves administration of fluids with lower osmolality than plasma, such as dextrose 5% in water or hypotonic saline solutions. This causes water to move into cells by osmosis, reducing extracellular fluid osmolality and serum sodium levels. It is used therapeutically to treat hypernatremia and certain conditions of fluid and electrolyte imbalance.","oneSentence":"Hypotonic hydration reduces serum osmolality by providing free water, diluting electrolytes and lowering plasma sodium concentration.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:47:55.737Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypernatremia"},{"name":"Dehydration with hypernatremia"},{"name":"Fluid and electrolyte imbalance"}]},"trialDetails":[{"nctId":"NCT05332015","phase":"NA","title":"The Effect of Oral Hypotonic Hydration in Isolated Oligohydramnios","status":"COMPLETED","sponsor":"Antalya Training and Research Hospital","startDate":"2022-04-28","conditions":"Oligohydramnios","enrollment":40},{"nctId":"NCT03304197","phase":"NA","title":"Hydration and Exercise Performance in Cycling","status":"COMPLETED","sponsor":"University of Exeter","startDate":"2017-09-11","conditions":"Healthy","enrollment":15},{"nctId":"NCT03343743","phase":"NA","title":"Changes in Renal Papillary Density After Hydration Therapy in Calcium Stone Formers","status":"COMPLETED","sponsor":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","startDate":"2013-06","conditions":"Urolithiasis","enrollment":25},{"nctId":"NCT00749827","phase":"PHASE4","title":"Renoprotective Effects of Fluid Prophylaxis Strategies for Contrast Induced Nephropathy (CIN)","status":"WITHDRAWN","sponsor":"Memorial University of Newfoundland","startDate":"","conditions":"Contrast Induced Nephropathy","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Dextrose(5%) in Water"],"phase":"marketed","status":"active","brandName":"Hypotonic hydration","genericName":"Hypotonic hydration","companyName":"Memorial University of Newfoundland","companyId":"memorial-university-of-newfoundland","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Hypotonic hydration reduces serum osmolality by providing free water, diluting electrolytes and lowering plasma sodium concentration. Used for Hypernatremia, Dehydration with hypernatremia, Fluid and electrolyte imbalance.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}