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The mechanism also involves modulation of inflammatory responses and restoration of cellular ion balance.","oneSentence":"Hypertonic saline (3% NaCl) draws fluid from intracellular and interstitial spaces into the intravascular compartment through osmotic gradient, reducing intracranial pressure and cerebral edema.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:45:24.987Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Elevated intracranial pressure / cerebral edema"},{"name":"Traumatic brain injury"},{"name":"Acute stroke management"}]},"trialDetails":[{"nctId":"NCT06441162","phase":"PHASE4","title":"Efficacy Of Combined Nebulized Hypertonic Saline and Chest Percussion Therapy in Acute Viral Bronchiolitis","status":"TERMINATED","sponsor":"NYU Langone Health","startDate":"2024-07-15","conditions":"Acute Bronchiolitis","enrollment":75},{"nctId":"NCT05480722","phase":"NA","title":"Central Sodium Sensing: Implications for Blood Pressure 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