{"id":"hypertonic-saline-7","safety":{"commonSideEffects":[{"rate":null,"effect":"Hyperchloremic acidosis"},{"rate":null,"effect":"Hypernatremia"},{"rate":null,"effect":"Phlebitis (with peripheral administration)"},{"rate":null,"effect":"Rebound intracranial pressure elevation"}]},"_chembl":{"chemblId":"CHEMBL2108783","moleculeType":"Unknown"},"_dailymed":{"setId":"0491c7e1-a05a-43f6-bdd4-3a6662f5e53e","title":"HYPERTONIC SALINE 7.2% (HYPERTONIC SALINE) INJECTION, SOLUTION [NOVA-TECH, INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The 7% sodium chloride solution is hypertonic relative to plasma, causing water to move osmotically from areas of lower solute concentration (brain tissue, cells) to areas of higher solute concentration (blood). This reduces brain edema and intracranial pressure. Additionally, hypertonic saline may have anti-inflammatory effects and improve microcirculatory flow.","oneSentence":"Hypertonic saline creates an osmotic gradient that draws fluid from intracellular and interstitial spaces into the vascular compartment, reducing intracranial pressure and cellular edema.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T03:50:42.150Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Elevated intracranial pressure (ICP) in traumatic brain injury"},{"name":"Cerebral edema"},{"name":"Increased intracranial pressure in neurocritical care settings"}]},"trialDetails":[{"nctId":"NCT04838223","phase":"","title":"Neurosensory Abnormalities in SymptomAtic Ocular Surface Patients (NASA)","status":"SUSPENDED","sponsor":"Tufts Medical Center","startDate":"2021-07-02","conditions":"Dry Eye, Neuropathic Pain","enrollment":1000},{"nctId":"NCT07350135","phase":"NA","title":"Sodium Supplementation and Growth in Premature Neonates","status":"ACTIVE_NOT_RECRUITING","sponsor":"Ain Shams University","startDate":"2025-11-06","conditions":"Sodium Supplementation and Growth in Premature Neonates","enrollment":74},{"nctId":"NCT06897761","phase":"NA","title":"Development of an Interactive Digital Respiratory Game and Device and Investigation of Its Effectiveness in Children With Bronchiectasis","status":"RECRUITING","sponsor":"Atlas University","startDate":"2025-10-07","conditions":"Bronchiectasis","enrollment":40},{"nctId":"NCT07286409","phase":"NA","title":"Nebulized Furosemide, Heparin, Hypertonic Saline in Mechanically Ventilated Acute Respiratory Distress Syndrome Adult Patients","status":"NOT_YET_RECRUITING","sponsor":"Tanta University","startDate":"2026-01","conditions":"Respiratory Distress Syndrome, Mechanical Ventilation Complication","enrollment":344},{"nctId":"NCT06411197","phase":"NA","title":"Exploration of Gait Biomechanics and Muscle Pain of the Lower Extremity","status":"RECRUITING","sponsor":"Kristian Kjær Petersen","startDate":"2023-11-08","conditions":"Pain, Acute","enrollment":36},{"nctId":"NCT06336109","phase":"NA","title":"Fragmented Sleep, Pain, and Biomechanics","status":"COMPLETED","sponsor":"Aalborg University","startDate":"2024-01-26","conditions":"Pain, Healthy, Sleep Disturbance","enrollment":30},{"nctId":"NCT06330402","phase":"NA","title":"Exploration of Gait Biomechanics and Pain","status":"COMPLETED","sponsor":"Kristian Kjær Petersen","startDate":"2023-09-26","conditions":"Pain, Healthy","enrollment":34},{"nctId":"NCT04921943","phase":"PHASE4","title":"Hypertonic Saline for MAC","status":"RECRUITING","sponsor":"Oregon Health and Science University","startDate":"2021-05-18","conditions":"Nontuberculous Mycobacterial Lung Disease, Nontuberculous Mycobacterium Infection","enrollment":50},{"nctId":"NCT06242795","phase":"PHASE4","title":"Hypertonic Saline in NCFB","status":"RECRUITING","sponsor":"University of North Carolina, Chapel Hill","startDate":"2024-10-23","conditions":"Bronchiectasis, Non-cystic Fibrosis Bronchiectasis","enrollment":20},{"nctId":"NCT03556683","phase":"NA","title":"Phase I Assessment of Hypertonic Saline in Moderate to Severe Asthmatics","status":"COMPLETED","sponsor":"University of North Carolina, Chapel Hill","startDate":"2018-10-01","conditions":"Moderate to Severe Asthma","enrollment":24},{"nctId":"NCT07088614","phase":"NA","title":"Effectiveness of Respiratory Physiotherapy on Frequency of Exacerbations, Lung Function and Quality of Life After 6 Months in Children With Cystic Fibrosis","status":"COMPLETED","sponsor":"University of Americas","startDate":"2022-10-28","conditions":"Cystic Fibrosis","enrollment":9},{"nctId":"NCT06914310","phase":"PHASE2, PHASE3","title":"Memantine as an Additive Therapy in Patients With Traumatic Brain Injury","status":"NOT_YET_RECRUITING","sponsor":"Mansoura University","startDate":"2025-03-25","conditions":"Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury (TBI)","enrollment":80},{"nctId":"NCT06310941","phase":"NA","title":"Mechanical Insufflation-exsufflation and Hypertonic Saline in Nosocomial Bacterial Respiratory Tract Infection","status":"NOT_YET_RECRUITING","sponsor":"Hospital San Carlos, Madrid","startDate":"2026-01-01","conditions":"Nosocomial Infection, Nosocomial Pneumonia, Tracheobronchitis","enrollment":100},{"nctId":"NCT03300648","phase":"PHASE3","title":"Treating Brain Swelling in Pediatric Cerebral Malaria","status":"COMPLETED","sponsor":"Michigan State University","startDate":"2018-01-08","conditions":"Malaria, Cerebral","enrollment":57},{"nctId":"NCT00753987","phase":"PHASE1","title":"Tolerability of Hypertonic Saline in Infants With Cystic Fibrosis","status":"COMPLETED","sponsor":"The Hospital for Sick Children","startDate":"2006-03","conditions":"Cystic Fibrosis","enrollment":13},{"nctId":"NCT06755697","phase":"NA","title":"Comparative Efficacy of Intra-articular vs. MRI-guided Extra-articular Dextrose Injections in Knee Osteoarthritis Management","status":"RECRUITING","sponsor":"Shin Kong Wu Ho-Su Memorial Hospital","startDate":"2025-01-23","conditions":"Knee Osteoarthritis, Glucose, Prolotherapy","enrollment":60},{"nctId":"NCT06503523","phase":"NA","title":"The Effects of Performing a Motor Imagery Task on Cortical Excitability During Acute Experimental Muscle Pain and Acute Itch","status":"RECRUITING","sponsor":"Aalborg University","startDate":"2024-10-01","conditions":"Itch, Pain","enrollment":30},{"nctId":"NCT06470737","phase":"NA","title":"Investigation of Corticospinal Excitability Aspects of Itch and Pain","status":"COMPLETED","sponsor":"Aalborg University","startDate":"2024-07-01","conditions":"Itch, Pain","enrollment":30},{"nctId":"NCT05819190","phase":"NA","title":"Testing the Efficacy in Adults With Cold of HEalsea Rescue*","status":"COMPLETED","sponsor":"Lallemand Pharma AG","startDate":"2022-12-14","conditions":"Common Cold","enrollment":200},{"nctId":"NCT06350461","phase":"NA","title":"Impact of Discontinuing Hypertonic Saline in People With CF on Highly Effective CFTR Modulators- A SIMPLIFY Sub-Study","status":"COMPLETED","sponsor":"Nicole Hamblett","startDate":"2020-08-25","conditions":"Cystic Fibrosis","enrollment":370},{"nctId":"NCT06478433","phase":"NA","title":"Study on the Efficacy and Safety of a Device for Post-op Recovery in Pediatric Adenectomy/Adenotonsillectomy.","status":"NOT_YET_RECRUITING","sponsor":"Pharmaluce srl","startDate":"2024-12-01","conditions":"Adenoidal Disorder, Tonsillitis, Otorhinolaryngologic Diseases","enrollment":90},{"nctId":"NCT06443658","phase":"PHASE3","title":"Benefits of Inhalation of Hypertonic Saline Solution Prior to Physiotherapy ELTGOL Technique in Bronchiectasis","status":"RECRUITING","sponsor":"Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta","startDate":"2024-06-01","conditions":"Bronchiectasis Adult","enrollment":57},{"nctId":"NCT00700050","phase":"","title":"Modulation by Sex Hormones of Inflammation and Susceptibility to Pseudomonas Aeruginosa in Cystic Fibrosis Airways","status":"COMPLETED","sponsor":"The Hospital for Sick Children","startDate":"2008-04","conditions":"Cystic Fibrosis","enrollment":28},{"nctId":"NCT02950883","phase":"PHASE2, PHASE3","title":"Saline Hypertonic in Preschoolers + CT","status":"COMPLETED","sponsor":"University of Washington, the Collaborative Health Studies Coordinating Center","startDate":"2015-03-24","conditions":"Cystic Fibrosis","enrollment":116},{"nctId":"NCT04787198","phase":"NA","title":"Investigating Composite Biomarkers for Pain Catastrophizing","status":"UNKNOWN","sponsor":"Aalborg University","startDate":"2022-10-15","conditions":"Pain, Acute","enrollment":44},{"nctId":"NCT04210726","phase":"NA","title":"Effect of Salt Solution Immersion Bath on Cancer in Vivo.","status":"WITHDRAWN","sponsor":"Rafik Batroussy","startDate":"2020-03","conditions":"Cancer","enrollment":""},{"nctId":"NCT05854589","phase":"PHASE2","title":"Effect of Topical Application of Hypertonic Saline on Melanoma on Its Sizes and Number.","status":"UNKNOWN","sponsor":"Rafik Batroussy","startDate":"2023-08-01","conditions":"Melanoma (Skin)","enrollment":20},{"nctId":"NCT02947126","phase":"PHASE1","title":"Multilevel Models of Therapeutic Response in the Lungs","status":"COMPLETED","sponsor":"Tim Corcoran","startDate":"2017-01","conditions":"Cystic Fibrosis","enrollment":56},{"nctId":"NCT00928135","phase":"PHASE1, PHASE2","title":"Aerosolized Hypertonic Xylitol Versus Hypertonic Saline in Cystic Fibrosis (CF) Subjects","status":"COMPLETED","sponsor":"Joseph Zabner","startDate":"2013-01-22","conditions":"Cystic Fibrosis","enrollment":63},{"nctId":"NCT03409237","phase":"","title":"Coagulation Activation by Hyperosmolar Agents in Intracranial Hypertension","status":"WITHDRAWN","sponsor":"Neuromed IRCCS","startDate":"2020-12-03","conditions":"Intracranial Hypertension, Cerebral Edema","enrollment":""},{"nctId":"NCT03623698","phase":"","title":"Nebulised Hypertonic Saline in Children and Young People With Neuromuscular Disease and Cerebral Palsy","status":"COMPLETED","sponsor":"Imperial College London","startDate":"2018-06-15","conditions":"Neuromuscular Diseases","enrollment":24},{"nctId":"NCT02378467","phase":"NA","title":"Saline Hypertonic in Preschoolers","status":"COMPLETED","sponsor":"University of Washington, the Collaborative Health Studies Coordinating Center","startDate":"2015-03-01","conditions":"Cystic Fibrosis","enrollment":150},{"nctId":"NCT03136042","phase":"NA","title":"Sputum Induction by Physiotherapy and Hypertonic Saline Techniques in Asthmatic Children","status":"COMPLETED","sponsor":"University of Sao Paulo","startDate":"2016-01-15","conditions":"Asthma","enrollment":33},{"nctId":"NCT03870646","phase":"PHASE3","title":"Nebulized hypErtonic Saline for Better Prevention of mUcus pLug in Critical Adult Tracheostomized Patients","status":"UNKNOWN","sponsor":"Hospital Universitario Virgen de la Arrixaca","startDate":"2019-04-01","conditions":"Critical Illness, Tracheostomy Complication, Mechanical Ventilation Complication","enrollment":164},{"nctId":"NCT02453750","phase":"NA","title":"Airway Inflammation in Congenital Diaphragmatic Hernia Patients","status":"COMPLETED","sponsor":"The Hospital for Sick Children","startDate":"2012-02","conditions":"Congenital Diaphragmatic Hernia","enrollment":21},{"nctId":"NCT02029040","phase":"NA","title":"Nebulized 3% Hypertonic Saline in the Treatment of Acute Bronchiolitis","status":"COMPLETED","sponsor":"University of Texas Southwestern Medical Center","startDate":"2013-12","conditions":"Acute Bronchiolitis","enrollment":52},{"nctId":"NCT01667666","phase":"PHASE1","title":"Clinical Trial of Nebulized Hypertonic Saline to Attenuate Post-Traumatic Acute Lung Injury","status":"TERMINATED","sponsor":"Denver Health and Hospital Authority","startDate":"2012-05","conditions":"Acute Lung Injury, Adult Respiratory Distress Syndrome","enrollment":13},{"nctId":"NCT01223183","phase":"PHASE1","title":"Absorptive Clearance After Inhaled Osmotics in Cystic Fibrosis","status":"COMPLETED","sponsor":"University of Pittsburgh","startDate":"2010-09","conditions":"Cystic Fibrosis","enrollment":20},{"nctId":"NCT01887197","phase":"PHASE1","title":"Repeatability and Response Study of Absorptive Clearance Scans","status":"COMPLETED","sponsor":"Tim Corcoran","startDate":"2013-06","conditions":"Cystic Fibrosis","enrollment":24},{"nctId":"NCT01355796","phase":"PHASE1, PHASE2","title":"Inhaled Xylitol Versus Saline in Stable Subjects With Cystic Fibrosis","status":"COMPLETED","sponsor":"Joseph Zabner","startDate":"2011-05","conditions":"Cystic Fibrosis","enrollment":30},{"nctId":"NCT03614273","phase":"NA","title":"Nebulized Hypertonic Saline (3%) Versus Nebulized Adrenaline for Treatment of Bronchiolitis","status":"COMPLETED","sponsor":"Maulana Azad Medical College","startDate":"2015-03-01","conditions":"Bronchiolitis","enrollment":60},{"nctId":"NCT01095354","phase":"","title":"Investigation of Lung Ventilation Inhomogeneity in Pediatric Asthma","status":"COMPLETED","sponsor":"The Hospital for Sick Children","startDate":"2009-11","conditions":"Asthma","enrollment":49},{"nctId":"NCT00410007","phase":"NA","title":"The Effect of High and Low Sodium Intake on Urinary Aquaporin-2 in Autosomal Dominant Polycystic Kidney Disease","status":"COMPLETED","sponsor":"Carolina Cannillo","startDate":"2006-10","conditions":"Polycystic Kidney, Autosomal Dominant","enrollment":29},{"nctId":"NCT01660867","phase":"PHASE4","title":"Nebulized 3% Hypertonic Saline in the Treatment of Acute Bronchiolitis in the Emergency Department","status":"WITHDRAWN","sponsor":"Seoul National University Hospital","startDate":"2012-08","conditions":"Acute Bronchiolitis","enrollment":""},{"nctId":"NCT03391414","phase":"PHASE1","title":"Effects of Inhaled Bicarbonate on Airway pH in Cystic Fibrosis","status":"COMPLETED","sponsor":"Joseph Pilewski","startDate":"2014-08","conditions":"Cystic Fibrosis","enrollment":12},{"nctId":"NCT02141191","phase":"PHASE1","title":"A Study of Lung Clearance After Hypertonic Saline Delivery Using the tPAD Device","status":"COMPLETED","sponsor":"University of Pittsburgh","startDate":"2014-06","conditions":"Cystic Fibrosis","enrollment":12},{"nctId":"NCT00671723","phase":"NA","title":"Dornase Alpha Versus Hypertonic Saline for Lung Atelectasis in Non-Cystic Fibrosis Patients","status":"COMPLETED","sponsor":"University of Oklahoma","startDate":"2006-10","conditions":"Atelectasis","enrollment":33},{"nctId":"NCT02341183","phase":"NA","title":"Novel Therapies for Muco-Obstructive Lung Diseases: Testing the Transnasal Pulmonary Delivery Device in COPD/CB Subjects","status":"WITHDRAWN","sponsor":"University of North Carolina, Chapel Hill","startDate":"2016-05","conditions":"COPD, Chronic Bronchitis","enrollment":""},{"nctId":"NCT01792271","phase":"NA","title":"Sustained Effects of Hypertonic Saline on Mucociliary Clearance in Subjects With Chronic Bronchitis","status":"COMPLETED","sponsor":"University of North Carolina, Chapel Hill","startDate":"2013-02","conditions":"Chronic Obstructive Pulmonary Disease, COPD, Chronic Bronchitis","enrollment":25},{"nctId":"NCT02392663","phase":"NA","title":"Sputum Clearance Effects of Hypertonic Saline in Non-cystic Fibrosis Bronchiectasis","status":"COMPLETED","sponsor":"Hospital Clinic of Barcelona","startDate":"2015-03","conditions":"Bronchiectasis","enrollment":24},{"nctId":"NCT01753869","phase":"NA","title":"Timing of Hypertonic Saline Inhalation Relative to Airways Clearance in Cystic Fibrosis","status":"TERMINATED","sponsor":"Belfast Health and Social Care Trust","startDate":"2012-12","conditions":"Cystic Fibrosis","enrollment":14},{"nctId":"NCT01945944","phase":"PHASE1, PHASE2","title":"Nebulized Hypertonic Saline for Mechanically Ventilated Children","status":"COMPLETED","sponsor":"University Hospitals Cleveland Medical Center","startDate":"2013-10","conditions":"Respiratory Failure","enrollment":18},{"nctId":"NCT02432157","phase":"PHASE1, PHASE2","title":"Safety and Feasibility of Hypertonic Saline Solution After Aneurysmal Subarachnoid Hemorrhage:","status":"UNKNOWN","sponsor":"Thomas Jefferson University","startDate":"2015-01","conditions":"Subarachnoid Hemorrhage, Cerebral Vasospasm, Hyponatremia","enrollment":50},{"nctId":"NCT02303808","phase":"NA","title":"Positive Expiratory Pressure During Inhalation of Hypertonic Saline in Patients With Cystic Fibrosis","status":"COMPLETED","sponsor":"Universidad San Jorge","startDate":"2014-12","conditions":"Cystic Fibrosis","enrollment":20},{"nctId":"NCT02253576","phase":"NA","title":"Inhaled Hypertonic Saline for Bronchiolitis","status":"WITHDRAWN","sponsor":"Queen's University","startDate":"2014-06","conditions":"Bronchiolitis","enrollment":""},{"nctId":"NCT01293084","phase":"PHASE2","title":"Hypertonic Saline and Mucociliary Clearance in Children","status":"COMPLETED","sponsor":"Johns Hopkins University","startDate":"2007-07","conditions":"Cystic Fibrosis","enrollment":17},{"nctId":"NCT01713595","phase":"PHASE1","title":"Safety Study of Inhaled Saline in Acute Lung Injury","status":"WITHDRAWN","sponsor":"Mayo Clinic","startDate":"2013-10","conditions":"Pulmonary Edema","enrollment":""},{"nctId":"NCT02276898","phase":"PHASE2","title":"A Randomized-Controlled Trial of Inhaled Hypertonic Saline (7%) to Evaluate the Lung Clearance Index","status":"COMPLETED","sponsor":"The Hospital for Sick Children","startDate":"2011-11","conditions":"Cystic Fibrosis","enrollment":24},{"nctId":"NCT01623661","phase":"NA","title":"Effect of Hypertonic Sodium Chloride on Urinary Biomarkers in Healthy Subjects and Patients With Chronic Kidney Disease","status":"COMPLETED","sponsor":"Regional Hospital Holstebro","startDate":"2011-12","conditions":"Nephropathy","enrollment":47},{"nctId":"NCT01635231","phase":"NA","title":"The Effect of Thiazide, Amiloride and Hypertonic Saline on Urinary Biomarkers in Healthy Subjects","status":"COMPLETED","sponsor":"Regional Hospital Holstebro","startDate":"2012-07","conditions":"Nephropathy","enrollment":24},{"nctId":"NCT00635141","phase":"PHASE3","title":"The Effect of Hypertonic Saline on the Lung Clearance Index in Patients With Cystic Fibrosis","status":"COMPLETED","sponsor":"The Hospital for Sick Children","startDate":"2008-03","conditions":"Cystic Fibrosis","enrollment":20},{"nctId":"NCT00721071","phase":"PHASE2","title":"Utility of Induced Sputum Using Hypertonic Saline to Evaluate Infection and Inflammation in Cystic Fibrosis","status":"COMPLETED","sponsor":"The Hospital for Sick Children","startDate":"2006-12","conditions":"Cystic Fibrosis","enrollment":95},{"nctId":"NCT01871857","phase":"PHASE4","title":"7% Hypertonic Saline for Acute Bronchiolitis","status":"COMPLETED","sponsor":"Le Bonheur Children's Hospital","startDate":"2010-11","conditions":"Acute Bronchiolitis","enrollment":101},{"nctId":"NCT01414088","phase":"NA","title":"The Effects of Isotonic and Hypertonic Saline Infusion on Renal Biomarkers in Healthy Young Subjects","status":"COMPLETED","sponsor":"Regional Hospital Holstebro","startDate":"2011-04","conditions":"Nephropathy","enrollment":23},{"nctId":"NCT00709280","phase":"NA","title":"Infant Study of Inhaled Saline in Cystic Fibrosis","status":"COMPLETED","sponsor":"CF Therapeutics Development Network Coordinating Center","startDate":"2009-04","conditions":"Cystic Fibrosis","enrollment":321},{"nctId":"NCT00903955","phase":"","title":"Mucus Dehydration and Evolution of Chronic Obstructive Pulmonary Disease (COPD) Lung Disease","status":"COMPLETED","sponsor":"University of North Carolina, Chapel Hill","startDate":"2006-09","conditions":"Chronic Obstructive Pulmonary Disease, Chronic Bronchitis","enrollment":100},{"nctId":"NCT01094704","phase":"PHASE1","title":"Durability of Hypertonic Saline for Enhancing Mucociliary Clearance in Cystic Fibrosis","status":"COMPLETED","sponsor":"University of North Carolina, Chapel Hill","startDate":"2009-11","conditions":"Cystic Fibrosis","enrollment":16},{"nctId":"NCT01658449","phase":"NA","title":"Comparison of the Tolerability of Two Formulations of Hypertonic Saline in Cystic Fibrosis Patients","status":"COMPLETED","sponsor":"Ospedale Civile Ca' Foncello","startDate":"2009-12","conditions":"Cystic Fibrosis","enrollment":40},{"nctId":"NCT00546663","phase":"NA","title":"Tolerability of Inhaled Hypertonic Saline in Infants With Cystic Fibrosis","status":"COMPLETED","sponsor":"CF Therapeutics Development Network Coordinating Center","startDate":"2007-09","conditions":"Cystic Fibrosis","enrollment":19},{"nctId":"NCT01216553","phase":"PHASE4","title":"Home Oxygen Therapy in Bronchiolitis","status":"UNKNOWN","sponsor":"Meir Medical Center","startDate":"2011-10","conditions":"Bronchiolitis","enrollment":135},{"nctId":"NCT00274391","phase":"PHASE2","title":"Efficacy of Amiloride and Hypertonic Saline in Cystic Fibrosis","status":"COMPLETED","sponsor":"University of North Carolina","startDate":"2001-07","conditions":"Cystic Fibrosis","enrollment":24}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":80,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Hypertonic Saline 7%","genericName":"Hypertonic Saline 7%","companyName":"The Hospital for Sick Children","companyId":"the-hospital-for-sick-children","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Hypertonic saline creates an osmotic gradient that draws fluid from intracellular and interstitial spaces into the vascular compartment, reducing intracranial pressure and cellular edema. Used for Elevated intracranial pressure (ICP) in traumatic brain injury, Cerebral edema, Increased intracranial pressure in neurocritical care settings.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}