{"id":"hypertonic-saline-3","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypernatremia"},{"rate":null,"effect":"Hyperchloremia"},{"rate":null,"effect":"Phlebitis at infusion site"},{"rate":null,"effect":"Rebound intracranial pressure elevation"},{"rate":null,"effect":"Dehydration"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The 3% sodium chloride solution creates an osmotic gradient that pulls water across cell membranes and from the interstitium into the bloodstream, thereby reducing brain edema and intracranial pressure. This osmotic diuretic effect is used acutely to manage elevated intracranial pressure and cerebral edema. The mechanism is purely physical/osmotic rather than receptor-mediated.","oneSentence":"Hypertonic saline 3% draws fluid from intracellular and interstitial spaces into the intravascular compartment through osmotic gradient, reducing intracranial pressure and cellular edema.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:33:12.669Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cerebral edema and elevated intracranial pressure"},{"name":"Traumatic brain injury"},{"name":"Acute stroke with cerebral edema"},{"name":"Intracranial hypertension"}]},"trialDetails":[{"nctId":"NCT01224704","phase":"NA","title":"Water Deprivation Protocol","status":"COMPLETED","sponsor":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","startDate":"2010-10-19","conditions":"Obesity","enrollment":75},{"nctId":"NCT06094816","phase":"PHASE4","title":"Forebrain Electroneutral Transporters in Salt-sensitive Hypertension: an MRI Study","status":"RECRUITING","sponsor":"University of Delaware","startDate":"2024-03-05","conditions":"Salt-Sensitivity of Blood Pressure","enrollment":120},{"nctId":"NCT07440173","phase":"PHASE4","title":"Phenol and Botulinum Toxin vs Botulinum Toxin Alone for Post-Stroke Upper-Limb Spasticity","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2026-05-01","conditions":"Spasticity as Sequela of Stroke","enrollment":60},{"nctId":"NCT06441162","phase":"PHASE4","title":"Efficacy Of Combined Nebulized Hypertonic Saline and Chest Percussion Therapy in Acute Viral Bronchiolitis","status":"TERMINATED","sponsor":"NYU Langone Health","startDate":"2024-07-15","conditions":"Acute Bronchiolitis","enrollment":75},{"nctId":"NCT06930300","phase":"NA","title":"Vasopressin in the Elderly: Physiological Changes in Neuroendocrine Function and Urinary Secretion in Healthy Aging","status":"COMPLETED","sponsor":"University Hospital, Basel, Switzerland","startDate":"2025-04-30","conditions":"Healthy Ageing","enrollment":32},{"nctId":"NCT07286409","phase":"NA","title":"Nebulized Furosemide, Heparin, Hypertonic Saline in Mechanically Ventilated Acute Respiratory Distress Syndrome Adult Patients","status":"NOT_YET_RECRUITING","sponsor":"Tanta University","startDate":"2026-01","conditions":"Respiratory Distress Syndrome, Mechanical Ventilation Complication","enrollment":344},{"nctId":"NCT05480722","phase":"NA","title":"Central Sodium Sensing: Implications for Blood Pressure Regulation","status":"COMPLETED","sponsor":"University of Delaware","startDate":"2022-06-01","conditions":"Salt Sensitivity of Blood Pressure","enrollment":29},{"nctId":"NCT07267897","phase":"NA","title":"Nebulized Lidocaine vs 3% Sodium Chloride in Pediatric Adenoid/Tonsil Surgery","status":"NOT_YET_RECRUITING","sponsor":"Sakarya University","startDate":"2026-03-15","conditions":"Postoperative Respiratory Complication","enrollment":90},{"nctId":"NCT07138625","phase":"NA","title":"Nebulized 3% Hypertonic Saline Versus Normal Saline in Managing Children With Acute Bronchiolitis: A Randomized Controlled Trial","status":"NOT_YET_RECRUITING","sponsor":"University Of Anbar","startDate":"2025-10-01","conditions":"Acute Bronchiolitis","enrollment":300},{"nctId":"NCT04921943","phase":"PHASE4","title":"Hypertonic Saline for MAC","status":"RECRUITING","sponsor":"Oregon Health and Science University","startDate":"2021-05-18","conditions":"Nontuberculous Mycobacterial Lung Disease, Nontuberculous Mycobacterium Infection","enrollment":50},{"nctId":"NCT05411991","phase":"PHASE4","title":"Diuretic Treatment in Acute Heart Failure With Volume Overload Guided by Serial Spot Urine Sodium Assessment","status":"COMPLETED","sponsor":"Vrije Universiteit Brussel","startDate":"2022-06-12","conditions":"Acute Heart Failure, Diuretics Drug Reactions","enrollment":107},{"nctId":"NCT03556683","phase":"NA","title":"Phase I Assessment of Hypertonic Saline in Moderate to Severe Asthmatics","status":"COMPLETED","sponsor":"University of North Carolina, Chapel Hill","startDate":"2018-10-01","conditions":"Moderate to Severe Asthma","enrollment":24},{"nctId":"NCT07088614","phase":"NA","title":"Effectiveness of Respiratory Physiotherapy on Frequency of Exacerbations, Lung Function and Quality of Life After 6 Months in Children With Cystic Fibrosis","status":"COMPLETED","sponsor":"University of Americas","startDate":"2022-10-28","conditions":"Cystic Fibrosis","enrollment":9},{"nctId":"NCT07060105","phase":"NA","title":"Hypertonic Saline for Mild TBI in Pediatric Patients","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Texas at Austin","startDate":"2023-11-01","conditions":"Head Injury, Minor, Pediatric, Emergency Department Patient","enrollment":74},{"nctId":"NCT06069336","phase":"NA","title":"Nebulised 3% Hypertonic Saline Versus 0.9% Saline for Treating Patients Hospitalized With Acute Bronchiolitis","status":"COMPLETED","sponsor":"Szpital im. 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