{"id":"hyperthermic-intraperitoneal-perfusion-chemotherapy","safety":{"commonSideEffects":[{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Myelosuppression"},{"rate":null,"effect":"Infection/peritonitis"},{"rate":null,"effect":"Bowel perforation"}]},"_chembl":{"chemblId":"CHEMBL3989695","moleculeType":"Small molecule","molecularWeight":"408.38"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This procedure involves circulating heated chemotherapy solution (typically mitomycin C or other agents) throughout the peritoneal cavity at elevated temperatures (40-43°C) to enhance drug penetration and cytotoxicity while minimizing systemic exposure. The combination of hyperthermia and direct peritoneal contact increases chemotherapy efficacy against peritoneal tumors, particularly those arising from or metastasizing to the peritoneum. The heat also enhances regional drug absorption and may trigger apoptosis in cancer cells.","oneSentence":"Hyperthermic intraperitoneal perfusion chemotherapy delivers heated chemotherapy drugs directly into the peritoneal cavity to treat peritoneal malignancies.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:15:15.850Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Peritoneal carcinomatosis"},{"name":"Ovarian cancer with peritoneal involvement"},{"name":"Gastric cancer with peritoneal metastases"},{"name":"Colorectal cancer with peritoneal involvement"}]},"trialDetails":[{"nctId":"NCT04847063","phase":"PHASE1","title":"Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal Histologies","status":"RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2021-10-19","conditions":"Peritoneal Mesothelioma, Peritoneal Carcinomatosis, Ovarian Cancer","enrollment":60},{"nctId":"NCT04415944","phase":"PHASE2","title":"Trial Evaluating Feasibility and Quality of Life of Second Look Laparoscopy With Hyperthermic Intraperitoneal Chemotherapy","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2021-05-20","conditions":"Ovarian Epithelial Cancer Stage I, Ovarian Epithelial Cancer Stage II, Ovarian Epithelial Cancer Stage III","enrollment":10},{"nctId":"NCT03842982","phase":"PHASE3","title":"Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Ovarian Cancer (CHIPPI)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Centre Oscar Lambret","startDate":"2019-05-03","conditions":"Ovary Neoplasms, Ovarian Cancer, Ovarian Carcinoma","enrollment":362},{"nctId":"NCT05316181","phase":"PHASE3","title":"CRS & HIPEC for Platinum-Resistant Recurrent Ovarian Cancer (KOV-02R, 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Used for Peritoneal carcinomatosis, Ovarian cancer with peritoneal involvement, Gastric cancer with peritoneal metastases.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}