{"id":"hyperosmolar-sodium-lactate","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypernatremia"},{"rate":null,"effect":"Hyperosmolality"},{"rate":null,"effect":"Phlebitis at infusion site"},{"rate":null,"effect":"Renal dysfunction"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The drug acts as an osmotic agent that creates an osmotic gradient across the blood-brain barrier. By increasing plasma osmolality, it promotes movement of water from the brain parenchyma into the vasculature, thereby reducing brain edema and intracranial pressure. The lactate component may also provide metabolic substrate and buffer capacity in hypoxic or ischemic conditions.","oneSentence":"Hyperosmolar sodium lactate increases serum osmolality to draw fluid from intracellular and interstitial spaces into the intravascular compartment, reducing intracranial pressure and improving cerebral perfusion.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:47:17.307Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Elevated intracranial pressure"},{"name":"Traumatic brain injury"},{"name":"Acute ischemic stroke"}]},"trialDetails":[{"nctId":"NCT01455376","phase":"NA","title":"Effect of Exogenous Lactate on Neurocognitive in Brain Trauma","status":"COMPLETED","sponsor":"Universitas Padjadjaran","startDate":"2010-03","conditions":"Traumatic Brain Injury","enrollment":60},{"nctId":"NCT01433276","phase":"PHASE3","title":"Efficacy, Safety of Solution Containing Hyperosmolar Sodium Lactate Infusion for Resuscitation of Patients With Hemorrhagic Shock","status":"COMPLETED","sponsor":"Innogene Kalbiotech Pte. Ltd","startDate":"2009-07","conditions":"Hemorrhagic Shock","enrollment":71}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":7,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Kalsolac","Totilac"],"phase":"phase_3","status":"active","brandName":"Hyperosmolar sodium lactate","genericName":"Hyperosmolar sodium lactate","companyName":"Innogene Kalbiotech Pte. Ltd","companyId":"innogene-kalbiotech-pte-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Hyperosmolar sodium lactate increases serum osmolality to draw fluid from intracellular and interstitial spaces into the intravascular compartment, reducing intracranial pressure and improving cerebral perfusion. Used for Elevated intracranial pressure, Traumatic brain injury, Acute ischemic stroke.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}