{"id":"hyperoncotic-albumin-20","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypervolemia / fluid overload"},{"rate":null,"effect":"Pulmonary edema"},{"rate":null,"effect":"Allergic reaction"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Chills"}]},"_chembl":{"chemblId":"CHEMBL1201451","moleculeType":"Protein"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Albumin is a natural plasma protein that acts as a colloid, exerting oncotic pressure that pulls fluid from the extravascular space into the bloodstream. The 20% concentration provides a hyperoncotic solution (higher albumin concentration than normal plasma), making it particularly effective for rapid intravascular volume expansion. This is used in acute settings where fluid shifts or hypovolemia require rapid restoration of circulating volume and hemodynamic stability.","oneSentence":"Hyperoncotic albumin 20% increases plasma oncotic pressure to draw fluid from interstitial spaces into the intravascular compartment, expanding blood volume and improving tissue perfusion.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:47:48.227Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypovolemic shock and acute blood loss requiring rapid volume expansion"},{"name":"Severe hypoalbuminemia with significant fluid shifts"},{"name":"Perioperative volume management in major surgery"}]},"trialDetails":[{"nctId":"NCT05208242","phase":"PHASE2, PHASE3","title":"Strong Albumin Solutions in Patients With Septic Shock","status":"COMPLETED","sponsor":"Manchester University NHS Foundation Trust","startDate":"2023-11-10","conditions":"Sepsis, Septic Shock, Shock, Toxic","enrollment":47},{"nctId":"NCT05391607","phase":"PHASE4","title":"Comparison Between Hyperoncotic and Isooncotic Albumin to Support Blood Loss Replacement","status":"COMPLETED","sponsor":"Insel Gruppe AG, University Hospital Bern","startDate":"2022-05-25","conditions":"Blood Loss, Surgical, Fluid Retention","enrollment":42},{"nctId":"NCT03848507","phase":"PHASE4","title":"Impact of Hyperoncotic Albumin to Support Blood Loss Replacement","status":"COMPLETED","sponsor":"Insel Gruppe AG, University Hospital Bern","startDate":"2019-03-18","conditions":"Blood Loss, Surgical, Fluid Retention","enrollment":24},{"nctId":"NCT02952378","phase":"PHASE4","title":"Volume Kinetics for Hyperoncotic Albumin in Burn Patients as Well as for Healthy Subjects","status":"COMPLETED","sponsor":"University Hospital, Linkoeping","startDate":"2016-10","conditions":"Burns","enrollment":30},{"nctId":"NCT03453320","phase":"PHASE4","title":"Infusion Rate and Volume Kinetics for Hyperoncotic Albumine in Healthy Subjects","status":"COMPLETED","sponsor":"University Hospital, Linkoeping","startDate":"2018-02-24","conditions":"Edema Secondary","enrollment":12}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":11,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Albumin 20%"],"phase":"marketed","status":"active","brandName":"Hyperoncotic Albumin 20%","genericName":"Hyperoncotic Albumin 20%","companyName":"Insel Gruppe AG, University Hospital Bern","companyId":"insel-gruppe-ag-university-hospital-bern","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Hyperoncotic albumin 20% increases plasma oncotic pressure to draw fluid from interstitial spaces into the intravascular compartment, expanding blood volume and improving tissue perfusion. Used for Hypovolemic shock and acute blood loss requiring rapid volume expansion, Severe hypoalbuminemia with significant fluid shifts, Perioperative volume management in major surgery.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}