{"id":"hyperhaes-vs-ra-solution-nacl","safety":{"commonSideEffects":[{"rate":null,"effect":"Hyperchloremic acidosis"},{"rate":null,"effect":"Acute kidney injury"},{"rate":null,"effect":"Coagulopathy"},{"rate":null,"effect":"Hypernatremia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"HyperHAES combines a hypertonic sodium chloride solution (7.2%) with hydroxyethyl starch (HES), creating a colloid with enhanced osmotic pressure that draws fluid into the intravascular space more efficiently than crystalloid solutions. This is intended to achieve faster hemodynamic stabilization and improved tissue perfusion with smaller infusion volumes, particularly in hemorrhagic shock or severe hypovolemia. The comparison trial evaluates whether this approach reduces fluid requirements and improves outcomes versus standard crystalloid resuscitation.","oneSentence":"HyperHAES is a hypertonic hydroxyethyl starch solution that restores intravascular volume and improves microcirculation through osmotic effects, compared to standard isotonic saline or Ringer's acetate.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:48:07.998Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hemorrhagic shock resuscitation"},{"name":"Severe hypovolemia requiring rapid fluid restoration"}]},"trialDetails":[{"nctId":"NCT00347477","phase":"PHASE3","title":"Fluid Shifts in Patients Treated With Therapeutic Hypothermia After Cardiac Arrest","status":"COMPLETED","sponsor":"Haukeland University Hospital","startDate":"2005-09","conditions":"Cardiac Arrest","enrollment":23}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"HyperHAES vs. RA-solution/NaCl","genericName":"HyperHAES vs. RA-solution/NaCl","companyName":"Haukeland University Hospital","companyId":"haukeland-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"HyperHAES is a hypertonic hydroxyethyl starch solution that restores intravascular volume and improves microcirculation through osmotic effects, compared to standard isotonic saline or Ringer's acetate. Used for Hemorrhagic shock resuscitation, Severe hypovolemia requiring rapid fluid restoration.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}