{"id":"hyperbaric-levobupivacaine-0-75","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Headache (post-dural puncture)"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Neurological toxicity (at high doses)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Levobupivacaine is the S-enantiomer of bupivacaine, a long-acting amide local anesthetic. It works by reversibly binding to and blocking voltage-gated sodium channels on the inner surface of nerve cell membranes, thereby preventing depolarization and conduction of nerve impulses. The hyperbaric formulation (containing dextrose) increases the density of the solution, allowing for more controlled spinal distribution during intrathecal administration.","oneSentence":"Levobupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:41:24.719Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Spinal anesthesia for surgical procedures"},{"name":"Regional anesthesia for lower limb and lower abdominal surgery"}]},"trialDetails":[{"nctId":"NCT04245774","phase":"PHASE4","title":"Comparing the Effects of Levobupivacaine and Bupivacaine in Saddle Spinal Anesthesia","status":"COMPLETED","sponsor":"Gazi University","startDate":"2007-11-21","conditions":"Outpatients, General Surgery, Anorectal Disorder","enrollment":60},{"nctId":"NCT02025374","phase":"PHASE4","title":"Hyperbaric Bupivacaine and Hyperbaric Levobupivacaine in C/S","status":"COMPLETED","sponsor":"Balikesir University","startDate":"2013-08","conditions":"Health Care, Drugs","enrollment":60},{"nctId":"NCT01881087","phase":"PHASE4","title":"Spinal Anesthesia With Hyperbaric Levobupivacaine 0.75% for Ambulatory Knee Arthroscopy","status":"COMPLETED","sponsor":"Fundacion Clinica Valle del Lili","startDate":"2006-06","conditions":"Disorder of Knee, Anesthesia","enrollment":180}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Bupinest 0.75% Pesado"],"phase":"marketed","status":"active","brandName":"Hyperbaric Levobupivacaine 0.75%","genericName":"Hyperbaric Levobupivacaine 0.75%","companyName":"Fundacion Clinica Valle del Lili","companyId":"fundacion-clinica-valle-del-lili","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Levobupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials. Used for Spinal anesthesia for surgical procedures, Regional anesthesia for lower limb and lower abdominal surgery.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}