{"id":"hyoscine-n-butyl-bromide-hbb","safety":{"commonSideEffects":[{"rate":null,"effect":"Dry mouth"},{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Blurred vision"},{"rate":null,"effect":"Urinary retention"},{"rate":null,"effect":"Tachycardia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"HBB competitively antagonizes muscarinic cholinergic receptors on smooth muscle in the gastrointestinal and urinary tracts, reducing involuntary contractions and spasms. As a quaternary ammonium compound, it is poorly absorbed systemically and acts primarily at peripheral sites, minimizing central nervous system effects. This results in antispasmodic and antisecretory effects useful in treating visceral pain and cramping.","oneSentence":"Hyoscine-N-butyl bromide is an anticholinergic agent that blocks muscarinic acetylcholine receptors to reduce smooth muscle spasms and secretions.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:41:18.216Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Abdominal pain and cramping associated with irritable bowel syndrome"},{"name":"Gastrointestinal spasms"},{"name":"Urinary tract spasms and dysuria"},{"name":"Biliary colic"}]},"trialDetails":[{"nctId":"NCT05911126","phase":"NA","title":"How to Reduce Pain in Patients Undergoing Office Hysteroscopy.","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2023-06-13","conditions":"Pain","enrollment":180},{"nctId":"NCT04349722","phase":"PHASE4","title":"The Effect of Hyoscine-N-butylbromide (HBB, Buscopan) in Augmented Labour Among Primigravidae","status":"COMPLETED","sponsor":"National University of Malaysia","startDate":"2019-12-01","conditions":"Labor Long","enrollment":110},{"nctId":"NCT03055390","phase":"PHASE4","title":"Effect of Intravenous Hyoscine Butylbromide Injection on Labour in High Risk Women","status":"COMPLETED","sponsor":"Cairo University","startDate":"2017-02-11","conditions":"Vaginal Delivery","enrollment":300},{"nctId":"NCT04125771","phase":"NA","title":"Diclofenac Potassium Alone Versus Diclofenac Potassium With Hyoscine-N-butyl Bromide (HBB in Endoscopy","status":"COMPLETED","sponsor":"Aljazeera Hospital","startDate":"2020-02-16","conditions":"Pain","enrollment":64},{"nctId":"NCT02098889","phase":"PHASE4","title":"Safety Study of Hyoscine N Butyl Bromide in Active Management of Labor","status":"COMPLETED","sponsor":"Sisli Hamidiye Etfal Training and Research Hospital","startDate":"2012-05","conditions":"Labor Fast","enrollment":382},{"nctId":"NCT01609855","phase":"PHASE4","title":"Does the Hyoscine N-Butylbromide Administered During Colonoscopy Increase the Adenoma Detection Rate?","status":"UNKNOWN","sponsor":"Valduce Hospital","startDate":"2012-01","conditions":"Colonic Adenomas","enrollment":400}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Molit amp."],"phase":"marketed","status":"active","brandName":"hyoscine-N-butyl bromide(HBB)","genericName":"hyoscine-N-butyl bromide(HBB)","companyName":"Sisli Hamidiye Etfal Training and Research Hospital","companyId":"sisli-hamidiye-etfal-training-and-research-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Hyoscine-N-butyl bromide is an anticholinergic agent that blocks muscarinic acetylcholine receptors to reduce smooth muscle spasms and secretions. Used for Abdominal pain and cramping associated with irritable bowel syndrome, Gastrointestinal spasms, Urinary tract spasms and dysuria.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}