{"id":"hyoscine-butylbromide-analgesics-non-narcotic","safety":{"commonSideEffects":[{"rate":null,"effect":"Dry mouth"},{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Blurred vision"},{"rate":null,"effect":"Urinary retention"},{"rate":null,"effect":"Tachycardia"}]},"_chembl":{"chemblId":"CHEMBL1256901","moleculeType":"Small molecule","molecularWeight":"440.38"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"By antagonizing muscarinic receptors on smooth muscle in the gastrointestinal and urinary tracts, hyoscine butylbromide decreases muscle contractions and spasmodic activity. This antispasmodic effect provides relief from cramping and pain associated with gastrointestinal disorders. The quaternary ammonium structure limits blood-brain barrier penetration, reducing central nervous system side effects compared to tertiary amines.","oneSentence":"Hyoscine butylbromide is an anticholinergic agent that blocks muscarinic acetylcholine receptors to reduce smooth muscle spasms and secretions.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:55:23.079Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Abdominal pain and cramping associated with irritable bowel syndrome"},{"name":"Gastrointestinal spasms and smooth muscle spasticity"}]},"trialDetails":[{"nctId":"NCT02582307","phase":"PHASE3","title":"Buscopan Versus Acetaminophen for Acute Abdominal Pain in Children","status":"COMPLETED","sponsor":"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","startDate":"2017-03-20","conditions":"Abdomen, Acute, Children","enrollment":236}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Buscopan"],"phase":"phase_3","status":"active","brandName":"Hyoscine butylbromide, Analgesics, Non-Narcotic","genericName":"Hyoscine butylbromide, Analgesics, Non-Narcotic","companyName":"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","companyId":"london-health-sciences-centre-research-institute-or-lawson-research-institute-of","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Hyoscine butylbromide is an anticholinergic agent that blocks muscarinic acetylcholine receptors to reduce smooth muscle spasms and secretions. Used for Abdominal pain and cramping associated with irritable bowel syndrome, Gastrointestinal spasms and smooth muscle spasticity.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}