{"id":"hylan-gf-20-alone","safety":{"commonSideEffects":[{"rate":"5-10","effect":"Injection site pain or swelling"},{"rate":"5-15","effect":"Transient joint effusion"},{"rate":"2-5","effect":"Knee pain exacerbation"}]},"_chembl":{"chemblId":"CHEMBL4297767","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Hylan GF-20 is a cross-linked hyaluronic acid derivative that mimics the properties of synovial fluid. It provides viscosupplementation by restoring the viscoelastic properties of degraded joint fluid, thereby reducing pain, improving joint mobility, and potentially slowing cartilage degeneration in osteoarthritic joints.","oneSentence":"Hylan GF-20 is a viscoelastic gel that lubricates and cushions the joint space to reduce friction and pain in osteoarthritis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:23:21.142Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Osteoarthritis of the knee"}]},"trialDetails":[{"nctId":"NCT03090698","phase":"PHASE4","title":"Outcomes of Injections in Patients Waiting for Total Knee Replacement","status":"UNKNOWN","sponsor":"Universidade Federal Fluminense","startDate":"2015-09","conditions":"Osteoarthritis of the Knee","enrollment":120},{"nctId":"NCT01335321","phase":"PHASE4","title":"Evaluation of the Effect of Adding Corticosteroid to Viscosupplementation","status":"COMPLETED","sponsor":"University of Sao Paulo General Hospital","startDate":"2011-03","conditions":"Osteoarthritis","enrollment":108},{"nctId":"NCT00253799","phase":"PHASE4","title":"A Safety Study of Hylan GF-20 to Treat Shoulder Osteoarthritis","status":"UNKNOWN","sponsor":"Northwestern Ophthalmic Institute S.C.","startDate":"2005-12","conditions":"Painful Shoulder Osteoarthritis","enrollment":35}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Synvisc One"],"phase":"marketed","status":"active","brandName":"Hylan GF-20 alone","genericName":"Hylan GF-20 alone","companyName":"University of Sao Paulo General Hospital","companyId":"university-of-sao-paulo-general-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Hylan GF-20 is a viscoelastic gel that lubricates and cushions the joint space to reduce friction and pain in osteoarthritis. Used for Osteoarthritis of the knee.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}