{"id":"hydroxyurea-treatment-hu","safety":{"commonSideEffects":[{"rate":null,"effect":"Myelosuppression (anemia, leukopenia, thrombocytopenia)"},{"rate":null,"effect":"Macrocytosis"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Hyperuricemia"},{"rate":null,"effect":"Elevated creatinine"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Hydroxyurea is a ribonucleotide reductase inhibitor that decreases deoxyribonucleotide pools, slowing DNA replication and cell division. In sickle cell disease, it increases fetal hemoglobin (HbF) expression, which does not polymerize and prevents red blood cell sickling. This reduces vaso-occlusive crises, hemolytic anemia, and organ damage.","oneSentence":"Hydroxyurea inhibits ribonucleotide reductase to reduce DNA synthesis and increase fetal hemoglobin production, reducing sickling and hemolysis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:55:05.048Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Sickle cell disease"},{"name":"Polycythemia vera"},{"name":"Essential thrombocythemia"},{"name":"Chronic myeloid leukemia"}]},"trialDetails":[{"nctId":"NCT05853458","phase":"PHASE4","title":"Evaluation of HU-resistance in Adult Patients With Polycythemia Vera Who Meet PV-AIM Predictors","status":"TERMINATED","sponsor":"Novartis Pharmaceuticals","startDate":"2023-07-28","conditions":"Polycythemia Vera","enrollment":76},{"nctId":"NCT05405114","phase":"PHASE2","title":"Research Study Investigating How Well NDec Works in People With Sickle Cell Disease","status":"COMPLETED","sponsor":"Novo Nordisk 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