{"id":"hydroxytyrosol-plus-vitamin-e","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbances"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Mild allergic reactions"}]},"_chembl":{"chemblId":"CHEMBL1950045","moleculeType":"Small molecule","molecularWeight":"154.16"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Hydroxytyrosol, a polyphenol from olive oil, and Vitamin E (tocopherol) are both potent antioxidants that scavenge free radicals and reduce lipid peroxidation. Together, they may provide complementary neuroprotective and anti-inflammatory effects, potentially protecting against oxidative damage in neurological conditions.","oneSentence":"Hydroxytyrosol and Vitamin E work synergistically as antioxidants to reduce oxidative stress and inflammation.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:55:20.226Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Neurological disorders associated with oxidative stress (specific indication under investigation in Phase 3)"}]},"trialDetails":[{"nctId":"NCT02842567","phase":"PHASE3","title":"Hydroxytyrosol and Vitamin E in Pediatric NASH","status":"COMPLETED","sponsor":"Bambino Gesù Hospital and Research Institute","startDate":"2017-04-01","conditions":"NAFLD","enrollment":80}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Hydroxytyrosol, alpha-tocopherol"],"phase":"phase_3","status":"active","brandName":"Hydroxytyrosol plus Vitamin E","genericName":"Hydroxytyrosol plus Vitamin E","companyName":"Bambino Gesù Hospital and Research Institute","companyId":"bambino-ges-hospital-and-research-institute","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Hydroxytyrosol and Vitamin E work synergistically as antioxidants to reduce oxidative stress and inflammation. Used for Neurological disorders associated with oxidative stress (specific indication under investigation in Phase 3).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}