{"id":"hydroxyethylstarch-130-0-4","safety":{"commonSideEffects":[{"rate":null,"effect":"Acute kidney injury"},{"rate":null,"effect":"Coagulopathy / increased bleeding"},{"rate":null,"effect":"Hyperchloremic acidosis"},{"rate":null,"effect":"Anaphylaxis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"HES 130/0.4 is a third-generation synthetic colloid composed of hydroxyethyl-substituted amylopectin with a mean molecular weight of 130 kDa and degree of substitution of 0.4. It functions as a volume expander by remaining in the intravascular space longer than crystalloids, thereby maintaining oncotic pressure and improving hemodynamic stability. The notation 130/0.4 indicates its molecular weight and substitution ratio, which influence its pharmacokinetic profile and clinical efficacy.","oneSentence":"Hydroxyethylstarch (HES) 130/0.4 is a synthetic colloid that expands intravascular volume by increasing plasma oncotic pressure and fluid retention in the bloodstream.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:40:52.698Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute blood loss and hypovolemia requiring volume replacement in perioperative and critical care settings"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Hydroxyethylstarch 130/0,4","genericName":"Hydroxyethylstarch 130/0,4","companyName":"Rigshospitalet, Denmark","companyId":"rigshospitalet-denmark","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Hydroxyethylstarch 130/0.4 is a type of colloid solution used in medical settings. It is not a small molecule, as per ChEMBL, but its exact modality is not specified in the provided facts.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}