{"id":"hydroxyethylpromethazine","rwe":[{"pmid":"4155913","year":"1974","title":"Comparison of the antihistaminic effects in skin of a tertiary (promethazine) and a quarternary phenothiazine (N-hydroxyethylpromethazine).","finding":"","journal":"Acta allergologica","studyType":"Clinical Study"},{"pmid":"4384451","year":"1968","title":"Effect of N-hydroxyethylpromethazine (Aprobit) on the tissue distribution and excretion of 35S-chlorpromazine in cats.","finding":"","journal":"European journal of pharmacology","studyType":"Clinical Study"},{"pmid":"4386346","year":"1968","title":"Effect on N-hydroxyethylpromethazine (Aprobit) on the distribution of 35S-chlorpromazine studied by autoradiography in cats and mice.","finding":"","journal":"Psychopharmacologia","studyType":"Clinical Study"},{"pmid":"14211229","year":"1964","title":"[EXPERIMENTAL CLINICAL TESTING OF N-HYDROXYETHYLPROMETHAZINE CHLORIDE (APROBIT) COMBINED WITH EPHEDRINE HYDROCHLORIDE IN THE NASAL CAVITY].","finding":"","journal":"Svenska lakartidningen","studyType":"Clinical Study"}],"tags":[{"label":"hydroxyethylpromethazine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"R06AD05","category":"atc"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["hydroxyethylpromethazine"],"offLabel":[],"synonyms":["hydroxyethylpromethazine"],"timeline":[],"approvals":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"hydroxyethylpromethazine","explanation":"Imagine your body has a system to regulate how you feel and react to things, and histamine is a key player in that system. Hydroxyethylpromethazine is thought to affect how histamine works, but we don't know exactly how it does that or what effects it has on the body. This can lead to changes in how you feel, such as drowsiness or relaxation.","oneSentence":"Hydroxyethylpromethazine is thought to work by interacting with the body's histamine receptors, but the exact details of its mechanism are unclear.","technicalDetail":"As a histamine receptor antagonist, hydroxyethylpromethazine is believed to compete with histamine for binding sites on histamine receptors, potentially leading to a decrease in histamine-mediated responses."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4571","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=hydroxyethylpromethazine","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:58:05.559707","biosimilars":[],"competitors":[{"drugName":"alimemazine","drugSlug":"alimemazine","fdaApproval":"","relationship":"same-class"},{"drugName":"promethazine","drugSlug":"promethazine","fdaApproval":"1951-03-29","genericCount":48,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"thiethylperazine","drugSlug":"thiethylperazine","fdaApproval":"1961-07-18","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"methdilazine","drugSlug":"methdilazine","fdaApproval":"","patentStatus":"Unknown","relationship":"same-class"}],"genericName":"hydroxyethylpromethazine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"alimemazine","brandName":"alimemazine","genericName":"alimemazine","approvalYear":"","relationship":"same-class"},{"drugId":"promethazine","brandName":"promethazine","genericName":"promethazine","approvalYear":"1951","relationship":"same-class"},{"drugId":"thiethylperazine","brandName":"thiethylperazine","genericName":"thiethylperazine","approvalYear":"1961","relationship":"same-class"},{"drugId":"methdilazine","brandName":"methdilazine","genericName":"methdilazine","approvalYear":"","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"571559SLAJ","UMLSCUI":"C3652684","ChEMBL_ID":"CHEMBL3707371","DRUGBANK_ID":"DB13840","PUBCHEM_CID":"16406"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":4,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"R06AD05","allCodes":["R06AD05","R06AD55"]},"biosimilarFilings":[],"recentPublications":[{"date":"1974 Dec","pmid":"4155913","title":"Comparison of the antihistaminic effects in skin of a tertiary (promethazine) and a quarternary phenothiazine (N-hydroxyethylpromethazine).","journal":"Acta allergologica"},{"date":"1968 Feb","pmid":"4384451","title":"Effect of N-hydroxyethylpromethazine (Aprobit) on the tissue distribution and excretion of 35S-chlorpromazine in cats.","journal":"European journal of pharmacology"},{"date":"1968","pmid":"4386346","title":"Effect on N-hydroxyethylpromethazine (Aprobit) on the distribution of 35S-chlorpromazine studied by autoradiography in cats and mice.","journal":"Psychopharmacologia"},{"date":"1964 Oct 14","pmid":"14211229","title":"[EXPERIMENTAL CLINICAL TESTING OF N-HYDROXYETHYLPROMETHAZINE CHLORIDE (APROBIT) COMBINED WITH EPHEDRINE HYDROCHLORIDE IN THE NASAL CAVITY].","journal":"Svenska lakartidningen"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"hydroxyethylpromethazine","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Hydroxyethylpromethazine is a small molecule with antihistamine and anticholinergic properties. It is structurally analogous to promethazine.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}