{"id":"hydroxycontin-acetominophen","safety":{"commonSideEffects":[{"rate":"25-50","effect":"Constipation"},{"rate":"20-40","effect":"Nausea"},{"rate":"15-30","effect":"Dizziness"},{"rate":"15-30","effect":"Drowsiness"},{"rate":"10-20","effect":"Vomiting"},{"rate":"1-5","effect":"Respiratory depression"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Hydrocodone binds to mu-opioid receptors in the central nervous system to reduce pain perception and transmission. Acetaminophen (paracetamol) inhibits cyclooxygenase enzymes and reduces prostaglandin synthesis, providing additional analgesic and antipyretic effects. The combination is used for moderate to moderately severe pain management.","oneSentence":"Hydrocodone (an opioid agonist) combined with acetaminophen provides analgesia through mu-opioid receptor activation and cyclooxygenase inhibition.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:23:22.661Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Moderate to moderately severe pain"}]},"trialDetails":[{"nctId":"NCT02932579","phase":"PHASE4","title":"Utility of Pharmacogenomic Testing and Postoperative Dental Pain Outcomes","status":"TERMINATED","sponsor":"University of Rochester","startDate":"2017-07-01","conditions":"Pain","enrollment":59}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":45,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Norco"],"phase":"marketed","status":"active","brandName":"hydroxycontin/acetominophen","genericName":"hydroxycontin/acetominophen","companyName":"University of Rochester","companyId":"university-of-rochester","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Hydrocodone (an opioid agonist) combined with acetaminophen provides analgesia through mu-opioid receptor activation and cyclooxygenase inhibition. Used for Moderate to moderately severe pain.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}