{"id":"hydroxychloroquine-z0188","safety":{"commonSideEffects":[{"rate":"null","effect":"Retinal toxicity"},{"rate":"null","effect":"Hearing loss"},{"rate":"null","effect":"Cardiac arrhythmias"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"It does this by interfering with the parasite's ability to digest hemoglobin, which is necessary for its survival. Hydroxychloroquine has also been found to have immunomodulatory effects, which may contribute to its therapeutic benefits in autoimmune diseases.","oneSentence":"Hydroxychloroquine is an antimalarial drug that works by inhibiting the growth and replication of Plasmodium parasites in the red blood cells.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:55:18.037Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Malaria"},{"name":"Rheumatoid Arthritis"},{"name":"Systemic Lupus Erythematosus"}]},"trialDetails":[{"nctId":"NCT01551069","phase":"PHASE3","title":"Multicenter Study Assessing the Efficacy & Safety of Hydroxychloroquine Sulfate in Patients With Systemic Lupus Erythematosus or Cutaneous Lupus Erythematosus With Active Lupus Erythematosus Specific Skin Lesion","status":"COMPLETED","sponsor":"Sanofi","startDate":"2012-03","conditions":"Cutaneous Lupus Erythematosus-Systemic Lupus Erythematosus","enrollment":103}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Plaquenil®"],"phase":"phase_3","status":"active","brandName":"hydroxychloroquine (Z0188)","genericName":"hydroxychloroquine (Z0188)","companyName":"Sanofi","companyId":"sanofi","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Hydroxychloroquine is an antimalarial drug that works by inhibiting the growth and replication of Plasmodium parasites in the red blood cells. Used for Malaria, Rheumatoid Arthritis, Systemic Lupus Erythematosus.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}