{"id":"hydroxychloroquine-in-combination-of-azithromycin","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"QT prolongation"},{"rate":null,"effect":"Retinopathy (hydroxychloroquine, long-term)"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Hydroxychloroquine is a quinoline antimalarial that raises endosomal pH and inhibits toll-like receptor signaling, potentially blocking viral entry and reducing inflammatory cytokine production. Azithromycin is a macrolide antibiotic with immunomodulatory properties that can reduce pro-inflammatory cytokine release. The combination was investigated for synergistic antiviral and anti-inflammatory effects.","oneSentence":"Hydroxychloroquine inhibits viral entry and endosomal acidification while azithromycin provides antimicrobial and immunomodulatory effects, together targeting viral replication and inflammatory response.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:55:12.542Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"COVID-19 (investigational, Phase 3)"}]},"trialDetails":[{"nctId":"NCT07443436","phase":"PHASE2","title":"Immunomodulatory Treatment of Interstitial Lung Disease Associated With Surfactant Related Gene Variants","status":"NOT_YET_RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2026-10-01","conditions":"Interstitial Lung Disease","enrollment":30},{"nctId":"NCT05894954","phase":"PHASE3","title":"Precision Medicine Approach for Early Dementia & Mild Cognitive Impairment","status":"COMPLETED","sponsor":"Alzheimer's Prevention and Reversal Project, Inc.","startDate":"2023-07-31","conditions":"Mild Cognitive Impairment, Dementia, Mild","enrollment":73},{"nctId":"NCT02735707","phase":"PHASE3","title":"Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia","status":"RECRUITING","sponsor":"UMC Utrecht","startDate":"2016-04-11","conditions":"Community-acquired Pneumonia, Influenza, COVID-19","enrollment":20000},{"nctId":"NCT04390594","phase":"PHASE3","title":"Efficacy and Safety Evaluation of Treatment Regimens in Adult COVID-19 Patients in Senegal","status":"TERMINATED","sponsor":"Institut Pasteur de Dakar","startDate":"2020-08-13","conditions":"COVID-19","enrollment":59},{"nctId":"NCT04381936","phase":"PHASE3","title":"Randomised Evaluation of COVID-19 Therapy","status":"RECRUITING","sponsor":"University of Oxford","startDate":"2020-03-19","conditions":"Severe Acute Respiratory Syndrome","enrollment":70000},{"nctId":"NCT04458948","phase":"PHASE2","title":"Non-comparative Trial of the Combination of HCQ and AZI in the Treatment of ICU Patients","status":"TERMINATED","sponsor":"University of New Mexico","startDate":"2020-03-24","conditions":"COVID-19","enrollment":28},{"nctId":"NCT04354428","phase":"PHASE2, PHASE3","title":"Treatment for COVID-19 in High-Risk Adult Outpatients","status":"TERMINATED","sponsor":"University of Washington","startDate":"2020-04-16","conditions":"COVID-19, SARS-CoV-2","enrollment":289},{"nctId":"NCT04394182","phase":"NA","title":"Ultra Low Doses of Therapy With Radiation Applicated to COVID-19","status":"SUSPENDED","sponsor":"Fundacion GenesisCare","startDate":"2020-04-21","conditions":"Pneumonia, Viral, Cytokine Storm","enrollment":15},{"nctId":"NCT05118984","phase":"PHASE4","title":"Efficacy of Azithromycin in MSAF Cases to Improve Maternal and Neonatal Outcomes","status":"COMPLETED","sponsor":"Cairo University","startDate":"2021-02-16","conditions":"Meconium Stained, Azithromycin, Postpartum Endometritis","enrollment":324},{"nctId":"NCT04346693","phase":"PHASE3","title":"An Open Randomized Study of Dalargin Efectiveness in Combination With Leitragin Drug in Patients With Severe and Critical Manifestations of SARS-COVID-19","status":"COMPLETED","sponsor":"Burnasyan Federal Medical Biophysical Center","startDate":"2020-04-08","conditions":"Acute Respiratory Tract Infection, Acute Respiratory Insufficiency, Pneumonia","enrollment":320},{"nctId":"NCT04358081","phase":"PHASE3","title":"Hydroxychloroquine Monotherapy and in Combination With Azithromycin in Patients With Moderate and Severe COVID-19 Disease","status":"COMPLETED","sponsor":"Novartis Pharmaceuticals","startDate":"2020-05-01","conditions":"Covid-19","enrollment":20},{"nctId":"NCT04353180","phase":"PHASE3","title":"Assessment the Activity Value of Isotretinoin (13- Cis-Retinoic Acid ) in the Treatment of COVID-19 ( Isotretinoin in Treatment of COVID-19) (Randomized)","status":"UNKNOWN","sponsor":"Kafrelsheikh University","startDate":"2021-08","conditions":"COVID19","enrollment":100000},{"nctId":"NCT04964583","phase":"PHASE2, PHASE3","title":"Hidroxicloroquina With Azitromicina Versus Hidroxicloroquina and Placebo Int Patients With Mild COVID-19","status":"UNKNOWN","sponsor":"Coordinación de Investigación en Salud, Mexico","startDate":"2021-01-20","conditions":"Covid19","enrollment":105},{"nctId":"NCT04380818","phase":"NA","title":"Low Dose Anti-inflammatory Radiotherapy for the Treatment of Pneumonia by COVID-19","status":"UNKNOWN","sponsor":"Grupo de Investigación Clínica en Oncología Radioterapia","startDate":"2020-06-05","conditions":"Pneumonia, Viral","enrollment":106},{"nctId":"NCT04933864","phase":"PHASE1","title":"COVID-19 Treatment Using Methylene Blue and Photodynamic Therapy","status":"COMPLETED","sponsor":"I.M. 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