{"id":"hydroxethyl-starch","safety":{"commonSideEffects":[{"rate":null,"effect":"Acute kidney injury"},{"rate":null,"effect":"Coagulopathy / increased bleeding"},{"rate":null,"effect":"Hyperchloremic acidosis"},{"rate":null,"effect":"Anaphylaxis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"HES is a glucose polymer derivative that remains in the intravascular space longer than crystalloid solutions, providing sustained volume expansion and improved hemodynamic stability. It is used as a plasma volume expander in acute blood loss and perioperative settings to restore circulating blood volume and maintain tissue perfusion without the need for immediate blood transfusion.","oneSentence":"Hydroxyethyl starch (HES) is a synthetic colloid that expands intravascular volume by increasing plasma oncotic pressure to maintain fluid balance during hemorrhage or hypovolemia.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:55:07.022Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute hypovolemia and hemorrhagic shock requiring volume replacement"},{"name":"Perioperative fluid management in surgical patients"}]},"trialDetails":[{"nctId":"NCT02502773","phase":"PHASE3","title":"Fluid Loading in Abdominal Surgery: Saline Versus Hydroxyethyl Starch (FLASH Study)","status":"COMPLETED","sponsor":"University Hospital, Clermont-Ferrand","startDate":"2016-02","conditions":"Postoperative Morbidity, Postoperative Mortality","enrollment":826}],"_emaApprovals":[],"_faersSignals":[{"count":1,"reaction":"HYPOTENSION"},{"count":1,"reaction":"LABORATORY TEST ABNORMAL"},{"count":1,"reaction":"OPERATIVE HAEMORRHAGE"}],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Hydroxethyl starch","genericName":"Hydroxethyl starch","companyName":"University Hospital, Clermont-Ferrand","companyId":"university-hospital-clermont-ferrand","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Hydroxyethyl starch (HES) is a synthetic colloid that expands intravascular volume by increasing plasma oncotic pressure to maintain fluid balance during hemorrhage or hypovolemia. Used for Acute hypovolemia and hemorrhagic shock requiring volume replacement, Perioperative fluid management in surgical patients.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}