{"id":"hydroquinine","rwe":[{"pmid":"39870847","year":"2025","title":"Electrophysiological characterization of human KCNT1 channel modulators and the therapeutic potential of hydroquinine and tipepidine in KCNT1 mutation-associated epilepsy mouse model.","finding":"","journal":"Acta pharmacologica Sinica","studyType":"Clinical Study"},{"pmid":"38247615","year":"2024","title":"Hydroquinine Enhances the Efficacy of Contact Lens Solutions for Inhibiting Pseudomonas aeruginosa Adhesion and Biofilm Formation.","finding":"","journal":"Antibiotics (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"37762218","year":"2023","title":"Hydroquinine Inhibits the Growth of Multidrug-Resistant Pseudomonas aeruginosa via the Suppression of the Arginine Deiminase Pathway Genes.","finding":"","journal":"International journal of molecular sciences","studyType":"Clinical Study"},{"pmid":"37502160","year":"2023","title":"Enhancing pDNA Delivery with Hydroquinine Polymers by Modulating Structure and Composition.","finding":"","journal":"JACS Au","studyType":"Clinical Study"},{"pmid":"37471456","year":"2023","title":"A Palladium-Catalyzed Borylation/Silica Gel Promoted Hydrolysis Sequence for the Synthesis of Hydroquinine-6'-Boric Acid and Its Applications.","finding":"","journal":"The Journal of organic chemistry","studyType":"Clinical Study"}],"tags":[{"label":"hydroquinine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"M09AA01","category":"atc"},{"label":"Active","category":"status"},{"label":"Anti-Arrhythmia Agents","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Parasympatholytics","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"dihydroquinine","offLabel":[],"synonyms":["hydroquinine","dihydroquinine"],"timeline":[],"approvals":[],"brandName":"Dihydroquinine","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"hydroquinine","explanation":"Imagine your cells are like tiny factories, and dihydroquinine is a tool that helps them work more efficiently. However, we don't know exactly how it fits into the factory or what it does to help the cells. More research is needed to understand how dihydroquinine affects the body.","oneSentence":"Dihydroquinine works by interacting with cellular processes, although the exact mechanism is unknown.","technicalDetail":"Dihydroquinine's mechanism of action is not well-characterized, but it is believed to involve interactions with cellular membranes and ion channels, potentially influencing cellular signaling pathways and processes."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4570","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=hydroquinine","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=hydroquinine","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:57:24.167788","biosimilars":[],"competitors":[{"drugName":"quinine","drugSlug":"quinine","fdaApproval":"2005-08-12","genericCount":5,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"hydroquinine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"quinine","brandName":"quinine","genericName":"quinine","approvalYear":"2005","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT00789165","phase":"PHASE2,PHASE3","title":"Empiric Quinidine for Asymptomatic Brugada Syndrome","status":"WITHDRAWN","sponsor":"International Registry of Asymptomatic Brugada Syndrome","startDate":"2009-12","conditions":["Arrhythmia"],"enrollment":0,"completionDate":"2020-12-31"},{"nctId":"NCT00927732","phase":"PHASE3","title":"Hydroquinidine Versus Placebo in Patients With Brugada Syndrome","status":"TERMINATED","sponsor":"Nantes University Hospital","startDate":"2009-02","conditions":["Brugada Syndrome"],"enrollment":64,"completionDate":"2014-10"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"31J3Q51T6L","CHEBI":"CHEBI:135994","RXNORM":"2468435","UMLSCUI":"C4316850","ChEMBL_ID":"CHEMBL2079611","DRUGBANK_ID":"DB13718","PUBCHEM_CID":"121515","MESH_SUPPLEMENTAL_RECORD_UI":"C014486"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":49,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"M09AA01","allCodes":["M09AA01"]},"biosimilarFilings":[],"recentPublications":[{"date":"2025 May","pmid":"39870847","title":"Electrophysiological characterization of human KCNT1 channel modulators and the therapeutic potential of hydroquinine and tipepidine in KCNT1 mutation-associated epilepsy mouse model.","journal":"Acta pharmacologica Sinica"},{"date":"2024 Jan 5","pmid":"38247615","title":"Hydroquinine Enhances the Efficacy of Contact Lens Solutions for Inhibiting Pseudomonas aeruginosa Adhesion and Biofilm Formation.","journal":"Antibiotics (Basel, Switzerland)"},{"date":"2023 Sep 10","pmid":"37762218","title":"Hydroquinine Inhibits the Growth of Multidrug-Resistant Pseudomonas aeruginosa via the Suppression of the Arginine Deiminase Pathway Genes.","journal":"International journal of molecular sciences"},{"date":"2023 Jul 24","pmid":"37502160","title":"Enhancing pDNA Delivery with Hydroquinine Polymers by Modulating Structure and Composition.","journal":"JACS Au"},{"date":"2023 Aug 4","pmid":"37471456","title":"A Palladium-Catalyzed Borylation/Silica Gel Promoted Hydrolysis Sequence for the Synthesis of Hydroquinine-6'-Boric Acid and Its Applications.","journal":"The Journal of organic chemistry"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Dihydroquinine, also known as hydroquinine, is a small molecule drug in the hydroquinine class. Its exact target and mechanism of action are unknown, but it is believed to work by interacting with cellular processes. Dihydroquinine is not FDA-approved for any indications, and its commercial status, including patent and generic availability, is unclear. Further research is needed to determine its safety and efficacy. As a result, dihydroquinine is not a widely recognized or used medication.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}