{"id":"hydrogen-rich-celsior-solution","safety":{"commonSideEffects":[]},"_chembl":{"chemblId":"CHEMBL2108251","moleculeType":"Oligosaccharide"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Molecular hydrogen acts as a selective antioxidant that neutralizes hydroxyl radicals and other reactive oxygen species generated during ischemia-reperfusion injury. By supplementing the standard Celsior organ preservation solution with hydrogen, the formulation aims to improve organ viability, reduce cellular damage, and enhance transplant outcomes. This approach targets the oxidative stress mechanism that occurs when blood flow is restored to previously ischemic organs.","oneSentence":"Hydrogen-rich Celsior solution reduces ischemic reperfusion injury by providing antioxidant protection through molecular hydrogen during organ preservation and transplantation.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:55:01.638Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Organ preservation for transplantation (kidney, liver, heart, or other solid organs)"},{"name":"Reduction of ischemia-reperfusion injury in organ transplantation"}]},"trialDetails":[{"nctId":"NCT02613195","phase":"PHASE3","title":"Clinical Trial of Hydrogen-Rich Celsior Solution Applied in Aging DBD Liver/Kidney Transplantation","status":"UNKNOWN","sponsor":"RenJi Hospital","startDate":"2016-01","conditions":"Evidence of Liver Transplantation","enrollment":20}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["HR solution"],"phase":"phase_3","status":"active","brandName":"Hydrogen-Rich Celsior Solution","genericName":"Hydrogen-Rich Celsior Solution","companyName":"RenJi Hospital","companyId":"renji-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Hydrogen-rich Celsior solution reduces ischemic reperfusion injury by providing antioxidant protection through molecular hydrogen during organ preservation and transplantation. Used for Organ preservation for transplantation (kidney, liver, heart, or other solid organs), Reduction of ischemia-reperfusion injury in organ transplantation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}