{"id":"hydrocortisone-butyrate-cream-0-1","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin atrophy"},{"rate":null,"effect":"Striae"},{"rate":null,"effect":"Telangiectasia"},{"rate":null,"effect":"Local irritation or burning"},{"rate":null,"effect":"Folliculitis"}]},"_chembl":{"chemblId":"CHEMBL3039247","moleculeType":"Small molecule","molecularWeight":"432.56"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Hydrocortisone butyrate is an ester prodrug of hydrocortisone that binds to glucocorticoid receptors in skin cells, inhibiting the production of pro-inflammatory cytokines and mediators. This reduces inflammation, itching, and other signs of dermatitis. The butyrate ester enhances skin penetration and provides sustained local activity with minimal systemic absorption.","oneSentence":"Hydrocortisone butyrate is a topical corticosteroid that suppresses local inflammatory and immune responses in the skin.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:40:03.067Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses (e.g., eczema, dermatitis, psoriasis)"}]},"trialDetails":[{"nctId":"NCT03539601","phase":"PHASE4","title":"A Study of Crisaborole Ointment 2%; Crisaborole Vehicle; TCS and TCI in Subjects Aged ≥ 2 Years, With Mild-moderate AD","status":"TERMINATED","sponsor":"Pfizer","startDate":"2018-04-27","conditions":"Atopic Dermatitis","enrollment":237},{"nctId":"NCT03766997","phase":"PHASE4","title":"Local Steroid Treatment for Idiopathic Granulomatous Mastitis (LSTIGM)","status":"UNKNOWN","sponsor":"Peking Union Medical College Hospital","startDate":"2019-02-19","conditions":"Granulomatous Mastitis","enrollment":100},{"nctId":"NCT03758365","phase":"PHASE1","title":"Evaluation of the Vasoconstriction Properties of MC2-01 Cream","status":"COMPLETED","sponsor":"MC2 Therapeutics","startDate":"2018-11-05","conditions":"Vasoconstriction","enrollment":36},{"nctId":"NCT03676933","phase":"PHASE2","title":"Efficacy and Steroid Sparing Potential Study of DGLA Cream in Early Childhood Patients With Moderate to Severe Atopic Dermatitis","status":"COMPLETED","sponsor":"DS Biopharma","startDate":"2015-10","conditions":"Atopic Dermatitis","enrollment":5},{"nctId":"NCT02959580","phase":"PHASE4","title":"Medical and Surgical Treatment for Idiopathic Granulomatous Mastitis","status":"UNKNOWN","sponsor":"Peking Union Medical College Hospital","startDate":"2017-01-01","conditions":"Granulomatous Mastitis","enrollment":100},{"nctId":"NCT00693693","phase":"PHASE4","title":"Adherence to Topical Hydrocortisone 17-butyrate 0.1% (Locoid®) Using Different Vehicles in Adults With Atopic Dermatitis","status":"COMPLETED","sponsor":"Wake Forest University","startDate":"2006-11","conditions":"Atopic Dermatitis","enrollment":26},{"nctId":"NCT02973776","phase":"PHASE1","title":"Vasoconstriction Trial With LEO 90100 Aerosol Foam","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2016-12","conditions":"Psoriasis Vulgaris","enrollment":36}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Locoid 0.1%"],"phase":"marketed","status":"active","brandName":"Hydrocortisone butyrate cream, 0.1%","genericName":"Hydrocortisone butyrate cream, 0.1%","companyName":"Pfizer","companyId":"pfizer","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Hydrocortisone butyrate is a topical corticosteroid that suppresses local inflammatory and immune responses in the skin. Used for Inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses (e.g., eczema, dermatitis, psoriasis).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}