{"id":"hydrocortisone-butyrate-0-1-cream","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin atrophy"},{"rate":null,"effect":"Striae"},{"rate":null,"effect":"Telangiectasia"},{"rate":null,"effect":"Folliculitis"},{"rate":null,"effect":"Burning or stinging at application site"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Hydrocortisone butyrate is an ester prodrug of hydrocortisone that binds to glucocorticoid receptors in skin cells, inhibiting the production of pro-inflammatory cytokines and mediators. This reduces inflammation, itching, and erythema in dermatological conditions. The butyrate ester enhances skin penetration and provides sustained local activity with reduced systemic absorption compared to unesterified hydrocortisone.","oneSentence":"Hydrocortisone butyrate is a topical corticosteroid that suppresses local inflammatory and immune responses in the skin.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:40:08.712Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Inflammatory and pruritic dermatoses responsive to topical corticosteroids (e.g., eczema, dermatitis, psoriasis)"}]},"trialDetails":[{"nctId":"NCT03539601","phase":"PHASE4","title":"A Study of Crisaborole Ointment 2%; Crisaborole Vehicle; TCS and TCI in Subjects Aged ≥ 2 Years, With Mild-moderate AD","status":"TERMINATED","sponsor":"Pfizer","startDate":"2018-04-27","conditions":"Atopic Dermatitis","enrollment":237},{"nctId":"NCT03766997","phase":"PHASE4","title":"Local Steroid Treatment for Idiopathic Granulomatous Mastitis (LSTIGM)","status":"UNKNOWN","sponsor":"Peking Union Medical College Hospital","startDate":"2019-02-19","conditions":"Granulomatous Mastitis","enrollment":100},{"nctId":"NCT03758365","phase":"PHASE1","title":"Evaluation of the Vasoconstriction Properties of MC2-01 Cream","status":"COMPLETED","sponsor":"MC2 Therapeutics","startDate":"2018-11-05","conditions":"Vasoconstriction","enrollment":36},{"nctId":"NCT03676933","phase":"PHASE2","title":"Efficacy and Steroid Sparing Potential Study of DGLA Cream in Early Childhood Patients With Moderate to Severe Atopic Dermatitis","status":"COMPLETED","sponsor":"DS Biopharma","startDate":"2015-10","conditions":"Atopic Dermatitis","enrollment":5},{"nctId":"NCT02959580","phase":"PHASE4","title":"Medical and Surgical Treatment for Idiopathic Granulomatous Mastitis","status":"UNKNOWN","sponsor":"Peking Union Medical College Hospital","startDate":"2017-01-01","conditions":"Granulomatous Mastitis","enrollment":100},{"nctId":"NCT00693693","phase":"PHASE4","title":"Adherence to Topical Hydrocortisone 17-butyrate 0.1% (Locoid®) Using Different Vehicles in Adults With Atopic Dermatitis","status":"COMPLETED","sponsor":"Wake Forest University","startDate":"2006-11","conditions":"Atopic Dermatitis","enrollment":26},{"nctId":"NCT02973776","phase":"PHASE1","title":"Vasoconstriction Trial With LEO 90100 Aerosol Foam","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2016-12","conditions":"Psoriasis Vulgaris","enrollment":36}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["ATC code H02AB09","Locoid® cream"],"phase":"marketed","status":"active","brandName":"Hydrocortisone Butyrate 0.1% Cream","genericName":"Hydrocortisone Butyrate 0.1% Cream","companyName":"Peking Union Medical College Hospital","companyId":"peking-union-medical-college-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Hydrocortisone butyrate is a topical corticosteroid that suppresses local inflammatory and immune responses in the skin. Used for Inflammatory and pruritic dermatoses responsive to topical corticosteroids (e.g., eczema, dermatitis, psoriasis).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}