{"id":"hydrochloric-acid","rwe":[{"pmid":"41902581","year":"2026","title":"Optimization of fermentation conditions and identification of active substances from Bacillus velezensis HZ33 for inhibiting Rhizoctonia solani in potato black scurf.","finding":"","journal":"Pest management science","studyType":"Clinical Study"},{"pmid":"41895009","year":"2026","title":"pH responsive Pickering emulsion stabilized by amphiphilic silicon quantum dots for enhancing oil recovery.","finding":"","journal":"Journal of colloid and interface science","studyType":"Clinical Study"},{"pmid":"41893278","year":"2026","title":"Highly Selective and Efficient Transport of Au(III), Pt(IV), and Pd(II) from Hydrochloric Acid Across Polymer Inclusion Membranes Containing Ionic Liquid as Ion Carrier.","finding":"","journal":"Membranes","studyType":"Clinical Study"},{"pmid":"41881909","year":"2026","title":"In vitro study on the neutralization potential of particulate hydroxyapatite in erosive acids.","finding":"","journal":"BDJ open","studyType":"Clinical Study"},{"pmid":"41874371","year":"2026","title":"Recirculation quantified by Trans-ECMO thermodilution to predict mixed venous oxygenation during V-V ECMO: an in vivo porcine study.","finding":"","journal":"Anesthesiology","studyType":"Clinical Study"}],"tags":[{"label":"hydrochloric acid","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Carbonic anhydrase 4","category":"target"},{"label":"CA4","category":"gene"},{"label":"A09AB03","category":"atc"},{"label":"Oral","category":"route"},{"label":"Liquid","category":"form"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{"safetySignals":[{"llr":52.936,"date":"","count":24,"signal":"Completed suicide","source":"DrugCentral FAERS","actionTaken":"Reported 24 times (LLR=53)"}],"commonSideEffects":[{"effect":"Completed suicide","drugRate":"LLR 53","severity":"common"}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["hydrochloric acid"],"offLabel":[],"synonyms":["hydrochloric acid"],"timeline":[],"approvals":[],"ecosystem":[],"mechanism":{"target":"Carbonic anhydrase 4","targets":[{"gene":"CA4","source":"DrugCentral","target":"Carbonic anhydrase 4","protein":"Carbonic anhydrase 4"}],"modality":"Small Molecule","drugClass":"hydrochloric acid","explanation":"Think of carbonic anhydrase 4 like a key that helps control the balance of fluids in the body. Hydrochloric acid blocks this key, which can help reduce fluid buildup in certain conditions. This can lead to relief from symptoms such as swelling and congestion.","oneSentence":"Hydrochloric acid works by inhibiting the enzyme carbonic anhydrase 4, which plays a role in various physiological processes.","technicalDetail":"Carbonic anhydrase 4 is a metalloenzyme that catalyzes the reversible reaction of carbon dioxide and water to form bicarbonate and a proton, playing a crucial role in maintaining acid-base balance and regulating fluid transport across cell membranes."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4568","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=hydrochloric%20acid","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=hydrochloric 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