{"id":"hyaluronic-acid-and-silver-sulfadiazine","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation or sensitization"},{"rate":null,"effect":"Allergic reaction to silver sulfadiazine"},{"rate":null,"effect":"Discoloration of wound area"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Hyaluronic acid is a natural polysaccharide that maintains moisture at the wound site, promoting epithelialization and reducing scarring. Silver sulfadiazine is a topical antimicrobial agent that releases silver ions to inhibit bacterial growth across a wide spectrum of pathogens. Together, they create an optimal environment for wound healing while preventing secondary infection.","oneSentence":"Hyaluronic acid provides a moist wound healing environment while silver sulfadiazine delivers broad-spectrum antimicrobial activity to prevent infection.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:24:22.928Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Burn wounds"},{"name":"Chronic wounds"},{"name":"Surgical wounds"},{"name":"Traumatic wounds"}]},"trialDetails":[{"nctId":"NCT06872151","phase":"PHASE4","title":"Evaluation of the Effectiveness of a Topical Medical Device in Wound Healing and Symptom Relief in the Postoperative Period of Open Excisional Hemorrhoidectomy (The Emor Study)","status":"COMPLETED","sponsor":"University of Cagliari","startDate":"2025-03-04","conditions":"Anus Diseases, Gastrointestinal Diseases, Intestinal Diseases","enrollment":114},{"nctId":"NCT04936204","phase":"NA","title":"Clinical Investigation to Evaluate the Safety and Performance of ConnettivinaBio Plus Cream Compared to ConnettivinaBio Cream in the Management of Wounds in Patients at High Risk of Infection","status":"UNKNOWN","sponsor":"Fidia Farmaceutici s.p.a.","startDate":"2021-06-10","conditions":"Wounds","enrollment":80},{"nctId":"NCT05447793","phase":"","title":"Effectiveness and Tolerability of Fitostimoline Plus vs Connettivina Bio Plus in Skin Graft","status":"UNKNOWN","sponsor":"Federico II University","startDate":"2021-01-18","conditions":"Wounds and Injuries, Skin Graft Scar, Skin Graft Complications","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":27,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Hyaluronic acid and silver sulfadiazine","genericName":"Hyaluronic acid and silver sulfadiazine","companyName":"University of Cagliari","companyId":"university-of-cagliari","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Hyaluronic acid provides a moist wound healing environment while silver sulfadiazine delivers broad-spectrum antimicrobial activity to prevent infection. Used for Burn wounds, Chronic wounds, Surgical wounds.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}