{"id":"hyaluronic-acid-0-05-ectoine-2-0","safety":{"commonSideEffects":[{"rate":null,"effect":"Mild ocular irritation"},{"rate":null,"effect":"Transient blurred vision"},{"rate":null,"effect":"Foreign body sensation"}]},"_chembl":{"chemblId":"CHEMBL5314376","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Hyaluronic acid is a natural humectant that binds water and lubricates the cornea and conjunctiva, reducing friction and improving tear film stability. Ectoine is an organic osmolyte that protects cells from dehydration and osmotic stress by stabilizing proteins and cell membranes, enhancing the eye's natural defense mechanisms against dry conditions.","oneSentence":"Hyaluronic acid and ectoine work together to hydrate and protect the ocular surface by retaining moisture and stabilizing cell membranes against osmotic stress.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:22:41.327Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Dry eye disease / Keratoconjunctivitis sicca"},{"name":"Ocular surface protection and lubrication"}]},"trialDetails":[{"nctId":"NCT03186755","phase":"PHASE4","title":"Clinical Evaluation of Hylo-Dual Versus Patanol in Children With Seasonal Allergic Conjunctivitis","status":"UNKNOWN","sponsor":"Michael Marchand, MD","startDate":"2017-06-11","conditions":"Conjunctivitis, Allergic, Conjunctivitis, Vernal","enrollment":42}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Hylo-Dual"],"phase":"marketed","status":"active","brandName":"Hyaluronic acid 0.05% & Ectoine 2.0%","genericName":"Hyaluronic acid 0.05% & Ectoine 2.0%","companyName":"Michael Marchand, MD","companyId":"michael-marchand-md","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Hyaluronic acid and ectoine work together to hydrate and protect the ocular surface by retaining moisture and stabilizing cell membranes against osmotic stress. Used for Dry eye disease / Keratoconjunctivitis sicca, Ocular surface protection and lubrication.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}