{"id":"huperzine-a-injection","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Muscle cramps"},{"rate":null,"effect":"Bradycardia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Huperzine A is a reversible inhibitor of the enzyme acetylcholinesterase, which normally breaks down the neurotransmitter acetylcholine. By blocking this enzyme, the drug increases acetylcholine concentration in the central nervous system, enhancing cholinergic neurotransmission. This mechanism is thought to improve memory, cognition, and neuronal protection in neurodegenerative conditions.","oneSentence":"Huperzine A inhibits acetylcholinesterase, increasing acetylcholine levels in the brain to improve cognitive function.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:23:24.591Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Alzheimer's disease"},{"name":"Age-related cognitive decline"},{"name":"Myasthenia gravis"}]},"trialDetails":[{"nctId":"NCT05242419","phase":"NA","title":"A Study of Huperzine A Injection in Reducing Postoperative Delirium in Elderly Patients Undergoing Non-cardiac Surgery","status":"RECRUITING","sponsor":"Second Affiliated Hospital of Wenzhou Medical University","startDate":"2022-06-10","conditions":"Injection, Non-cardiac Surgery, Delirium in Old Age","enrollment":40},{"nctId":"NCT06570655","phase":"PHASE1","title":"The Study of Pharmacokinetics and Pharmacodynamics of Huperzine a Injection in Healthy Chinese Subjects","status":"COMPLETED","sponsor":"Wanbangde Pharmaceutical Group Co., LTD","startDate":"2024-05-16","conditions":"Healthy Subjects","enrollment":12},{"nctId":"NCT06704334","phase":"PHASE4","title":"The Study of Ginkgo Leaf Dropping Pills and Huperzine a Injection Combined with Median Nerve Electrical Stimulation in the Treatment of Cognitive Impairment After Brain Injury","status":"RECRUITING","sponsor":"Wanbangde Pharmaceutical Group Co., LTD","startDate":"2024-04-01","conditions":"Cognitive Impairment After Brain Injury","enrollment":50},{"nctId":"NCT05560373","phase":"PHASE4","title":"The Effect of Huperzine A Injection on Postoperative Cognitive Dysfunction in Patients With Aneurysmal Subarachnoid Hemorrhage: a Pilot Study","status":"UNKNOWN","sponsor":"Wanbangde Pharmaceutical Group Co., LTD","startDate":"2022-09-30","conditions":"Postoperative Cognitive Dysfunction in Patients With Aneurysmal Subarachnoid Hemorrhage","enrollment":60},{"nctId":"NCT04509323","phase":"PHASE4","title":"Clinical Study of Huperzine A in the Treatment of Patients With Hypertensive Cerebral Hemorrhage","status":"UNKNOWN","sponsor":"Jiangsu Famous Medical Technology Co., Ltd.","startDate":"2020-08-03","conditions":"Neurosensory Disorder","enrollment":20}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Huperzine A Injection","genericName":"Huperzine A Injection","companyName":"Second Affiliated Hospital of Wenzhou Medical University","companyId":"second-affiliated-hospital-of-wenzhou-medical-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Huperzine A inhibits acetylcholinesterase, increasing acetylcholine levels in the brain to improve cognitive function. Used for Alzheimer's disease, Age-related cognitive decline, Myasthenia gravis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}