{"id":"humia-inj","safety":{"commonSideEffects":[{"rate":null,"effect":"Local injection site reactions"},{"rate":null,"effect":"Hypersensitivity reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Humia works by enzymatically degrading hyaluronic acid in the extracellular matrix, temporarily increasing tissue permeability. This mechanism allows co-administered drugs to diffuse more effectively through tissues, improving bioavailability and therapeutic efficacy. It is used as an adjuvant to enhance the spread and absorption of other injectable medications.","oneSentence":"Humia is a recombinant human hyaluronidase injection designed to enhance tissue permeability and facilitate drug distribution.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:48:04.002Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Adjuvant to enhance subcutaneous or intradermal administration of other drugs (phase 3 development)"}]},"trialDetails":[{"nctId":"NCT02893098","phase":"PHASE3","title":"A Study to Evaluate the Safety and Efficacy of Humia Inj. in Patients With Symptomatic Osteoarthritis of the Knee","status":"COMPLETED","sponsor":"Huons Co., Ltd.","startDate":"2016-08","conditions":"Osteoarthritis of Knee","enrollment":232}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Humia inj.","genericName":"Humia inj.","companyName":"Huons Co., Ltd.","companyId":"huons-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Humia is a recombinant human hyaluronidase injection designed to enhance tissue permeability and facilitate drug distribution. Used for Adjuvant to enhance subcutaneous or intradermal administration of other drugs (phase 3 development).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}