{"id":"human-recombinant-erythropoietin","safety":{"commonSideEffects":[{"rate":"20-30","effect":"Hypertension"},{"rate":"1-5","effect":"Thrombosis (venous and arterial)"},{"rate":"10-20","effect":"Headache"},{"rate":"5-10","effect":"Fever"},{"rate":"5-15","effect":"Injection site reactions"},{"rate":"<1","effect":"Pure red cell aplasia (rare)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Erythropoietin is a glycoprotein hormone that regulates erythropoiesis by promoting proliferation, differentiation, and maturation of erythroid progenitor cells. By mimicking endogenous EPO, the recombinant form increases hemoglobin and hematocrit levels, improving oxygen-carrying capacity of blood. This is used therapeutically to treat anemia in various clinical contexts.","oneSentence":"Human recombinant erythropoietin (rHuEPO) binds to erythropoietin receptors on erythroid progenitor cells in bone marrow to stimulate red blood cell production.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:40:28.012Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Anemia associated with chronic kidney disease"},{"name":"Anemia in cancer patients receiving chemotherapy"},{"name":"Anemia in patients undergoing surgery with anticipated blood loss"}]},"trialDetails":[{"nctId":"NCT07160452","phase":"PHASE4","title":"Levocarnitine for Reducing ESA Requirements in Hemodialysis Patients With Renal Anemia","status":"NOT_YET_RECRUITING","sponsor":"Shaikh Zayed Hospital, Lahore","startDate":"2025-09-15","conditions":"Anemia, Kidney Failure, End-Stage Renal Disease","enrollment":94},{"nctId":"NCT07045155","phase":"PHASE4","title":"Pegmolesatide Treatment for 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