{"id":"human-papillomavirus","safety":{"commonSideEffects":[{"rate":"50-80","effect":"Injection site pain, erythema, or swelling"},{"rate":"10-15","effect":"Fever"},{"rate":"10-20","effect":"Headache"},{"rate":"5-10","effect":"Myalgia"},{"rate":"5-10","effect":"Nausea"}]},"_chembl":null,"_dailymed":{"setId":"de399089-a0b3-4d43-b1e9-fc361a91095b","title":"HUMAN PAPILLOMAVIRUS COMBINATION 4019 (HUMAN PAPILLOMAVIRUS COMBINATION) LIQUID [PROFESSIONAL COMPLEMENTARY HEALTH FORMULAS]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"HPV vaccines contain virus-like particles (VLPs) derived from the major capsid protein of HPV, which trigger both humoral and cellular immune responses. These responses generate protective antibodies that prevent viral infection of epithelial cells, thereby reducing the risk of HPV-related cancers including cervical, anal, oropharyngeal, and other malignancies. The vaccine is typically administered as a series of intramuscular injections in adolescents and young adults.","oneSentence":"Human Papillomavirus (HPV) vaccines stimulate the immune system to produce antibodies against specific HPV types, preventing infection and associated cancers.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T04:02:09.074Z","_scrapedBy":"cloudflare-swarm","_wikipedia":{"url":"https://en.wikipedia.org/wiki/Human_papillomavirus_infection","title":"Human papillomavirus infection","extract":"Human papillomavirus infection is an infection caused by a DNA virus from the Papillomaviridae family. Many HPV infections cause no symptoms and 90% resolve spontaneously within two years. Sometimes an HPV infection persists and results in warts or precancerous lesions. Many warts are caused by HPV. These lesions, depending on the site affected, increase the risk of cancer of the cervix, vulva, vagina, penis, anus, mouth, tonsils, or throat. Nearly all cervical cancer is due to HPV and two strains, HPV16 and HPV18, account for 70% of all cases. HPV16 is responsible for almost 90% of HPV-related cancers of the mouth, throat, or tonsils. Between 60% and 90% of the other cancers listed above are also linked to HPV. HPV6 and HPV11 are common causes of genital warts and laryngeal papillomatosis."},"indications":{"approved":[{"name":"Prevention of cervical cancer and precancerous lesions caused by HPV types 16 and 18"},{"name":"Prevention of anal, oropharyngeal, and other HPV-related cancers"},{"name":"Prevention of genital warts caused by HPV types 6 and 11 (in multivalent formulations)"}]},"trialDetails":[{"nctId":"NCT01011712","phase":"","title":"The Natural History of Severe Viral Infections and Characterization of Immune Defects in Patients Without Known Immunocompromise","status":"RECRUITING","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2009-10-01","conditions":"EBV, HSV, VZV","enrollment":600},{"nctId":"NCT06223568","phase":"PHASE2","title":"Phase II Trial of Neoadjuvant Chemotherapy (NAC) Alone or in Combination With Immunotherapy Vaccine PRGN-2009 in Subjects With Newly Diagnosed HPV-Associated Oropharyngeal (Head and Neck) Cancer","status":"RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2024-06-10","conditions":"Squamous Cell Carcinoma of the Head and Neck, Oropharynx, Human Papillomavirus Viruses","enrollment":70},{"nctId":"NCT07407569","phase":"PHASE2","title":"Developing a First-void Urine-based Infection Model to Study HPV-specific Antibody-virion Interaction Before and After HPV Vaccination","status":"RECRUITING","sponsor":"Universiteit Antwerpen","startDate":"2026-03-25","conditions":"Human Papilloma Virus Infection Type 16","enrollment":50},{"nctId":"NCT02568566","phase":"PHASE2","title":"Recombinant Human Papillomavirus Nonavalent Vaccine in Preventing Human Papilloma Virus in Younger Healthy Participants","status":"ACTIVE_NOT_RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2016-05-19","conditions":"Human Papillomavirus-Related Carcinoma","enrollment":201},{"nctId":"NCT05985681","phase":"PHASE1","title":"Testing RG1-VLP Vaccine to Prevent HPV-related 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