{"id":"human-histaglobulin","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Fever"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This drug is derived from pooled human plasma and contains antibodies against histamine and other mediators of allergic and inflammatory responses. It works by binding histamine and other inflammatory mediators, reducing their bioavailability, and stabilizing mast cells to prevent degranulation. This mechanism helps attenuate allergic and inflammatory reactions in conditions characterized by excessive histamine release.","oneSentence":"Human histaglobulin is a polyclonal immunoglobulin preparation that modulates immune responses by providing passive immunization and stabilizing mast cells to reduce histamine release.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:32:51.798Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Allergic diseases and conditions"},{"name":"Urticaria"},{"name":"Allergic rhinitis"}]},"trialDetails":[{"nctId":"NCT06250400","phase":"PHASE4","title":"Efficacy and Safety of Histamine Human Immunoglobulin in the Treatment of Chronic Spontaneous Urticaria (CSU)","status":"UNKNOWN","sponsor":"Hangzhou Grand Biologic Pharmaceutical, Inc.","startDate":"2024-03-31","conditions":"Chronic Spontaneous Urticaria","enrollment":252}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":19,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"human histaglobulin","genericName":"human histaglobulin","companyName":"Hangzhou Grand Biologic Pharmaceutical, Inc.","companyId":"hangzhou-grand-biologic-pharmaceutical-inc","modality":"Biologic","firstApprovalDate":"","aiSummary":"Human histaglobulin is a polyclonal immunoglobulin preparation that modulates immune responses by providing passive immunization and stabilizing mast cells to reduce histamine release. Used for Allergic diseases and conditions, Urticaria, Allergic rhinitis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}