{"id":"human-albumin-colloid","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypervolemia / fluid overload"},{"rate":null,"effect":"Pulmonary edema"},{"rate":"rare","effect":"Allergic reaction"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Chills"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Human albumin is a naturally occurring plasma protein that functions as a volume expander in the intravascular space. It exerts oncotic pressure that draws and retains fluid within blood vessels, preventing fluid shift into the interstitium. This mechanism is used to restore hemodynamic stability in conditions characterized by hypovolemia or severe protein loss.","oneSentence":"Human albumin acts as a colloid to expand intravascular volume and maintain oncotic pressure, thereby restoring circulating blood volume and tissue perfusion.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:32:45.646Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypovolemic shock and acute blood loss"},{"name":"Severe burns"},{"name":"Hypoproteinemia and malnutrition"},{"name":"Liver cirrhosis with ascites"},{"name":"Nephrotic syndrome"}]},"trialDetails":[{"nctId":"NCT07212582","phase":"PHASE3","title":"Human Albumin for Resuscitation in Surgical Septic Shock: A Randomized Controlled Trial (ALBUS Study)","status":"NOT_YET_RECRUITING","sponsor":"Mahidol University","startDate":"2025-12-01","conditions":"Critical Illness, Septic Shock","enrollment":304},{"nctId":"NCT03461900","phase":"NA","title":"Guided Fluid-balance Optimization With Mini-fluid chALlenge During Septic Shock","status":"COMPLETED","sponsor":"University Hospital, Brest","startDate":"2019-06-04","conditions":"Septic Shock","enrollment":535},{"nctId":"NCT06654687","phase":"NA","title":"Transthoracic Echocardiographic Monitoring of Cardiac Output Effects of Colloid Preload and Crystalloid Coload During Cesarean Delivery Under Spinal Anesthesia","status":"COMPLETED","sponsor":"Sameh Fathy","startDate":"2024-10-27","conditions":"Pregnancy, Cesarean Delivery, Spinal Anesthesia Induced Hypotension","enrollment":162},{"nctId":"NCT05647057","phase":"NA","title":"CPB Prime Fluid Strategies to Preserve Mcirocirculatory Perfusion","status":"COMPLETED","sponsor":"Amsterdam UMC, location VUmc","startDate":"2023-07-10","conditions":"Endothelial Dysfunction, Hemolysis, Fluid Overload","enrollment":48},{"nctId":"NCT06107335","phase":"PHASE4","title":"Effect of Albumin Versus Routine Care on Hemodynamic Response and Stability in Patients With Preeclampsia Guided by a Non-invasive Hemodynamic Monitoring System During Cesarean Delivery With Spinal Anesthesia","status":"NOT_YET_RECRUITING","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2025-07-01","conditions":"Pre-Eclampsia","enrollment":62},{"nctId":"NCT06681415","phase":"PHASE4","title":"Efficacy of 20% Human Albumin in Reducing Pleural Effusion After Cardiopulmonary Bypass","status":"COMPLETED","sponsor":"Pauls Stradins Clinical University Hospital","startDate":"2022-09-01","conditions":"Pleural Effusions Post Coronary Artery Bypass Graft, Hypoxia, Hypoalbuminemia","enrollment":70},{"nctId":"NCT04356859","phase":"NA","title":"The Acute Burn ResUscitation Multicenter Prospective Trial","status":"UNKNOWN","sponsor":"American Burn Association","startDate":"2021-04-22","conditions":"Burn Injury","enrollment":400},{"nctId":"NCT00006099","phase":"PHASE1","title":"Monoclonal Antibody Therapy in Treating Patients Scheduled for Surgery to Remove Ovarian Cancer","status":"TERMINATED","sponsor":"Ludwig Institute for Cancer Research","startDate":"2000-08-02","conditions":"Ovarian Cancer","enrollment":1},{"nctId":"NCT05647200","phase":"NA","title":"Optimization of Prime Fluid Strategy to Preserve Microcirculatory Perfusion During Cardiac Surgery With Cardiopulmonary Bypass, Part II","status":"UNKNOWN","sponsor":"Amsterdam UMC, location VUmc","startDate":"2023-10-15","conditions":"Endothelial Dysfunction, Hemolysis, Fluid Overload","enrollment":64},{"nctId":"NCT05033704","phase":"NA","title":"Effect of Human Plasma Protein Transfusion With and Without Crystalloids During Major Liver Resection Surgeries","status":"UNKNOWN","sponsor":"Hamad Medical Corporation","startDate":"2019-09-09","conditions":"Coagulation; Intravascular, Fluid Electrolyte Disorders","enrollment":48},{"nctId":"NCT03900104","phase":"NA","title":"Cervical and Endometrial Injection for Sentinel Lymph Node Detection in Endometrial Cancer","status":"COMPLETED","sponsor":"Kocaeli University","startDate":"2019-05-01","conditions":"Endometrial Cancer, Sentinel Lymph Node","enrollment":81},{"nctId":"NCT03306914","phase":"NA","title":"Comparing Human Albumin Versus Hydroxyethylstarch in Renal Transplant Recipients","status":"COMPLETED","sponsor":"Cairo University","startDate":"2017-10-15","conditions":"Anesthesia Morbidity","enrollment":120},{"nctId":"NCT02654782","phase":"PHASE2","title":"Lactated Ringer's Versus 5% Human Albumin: Cardiac Surgical Patients","status":"TERMINATED","sponsor":"William C. 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Used for Hypovolemic shock and acute blood loss, Severe burns, Hypoproteinemia and malnutrition.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}