{"id":"hualan-tiv","safety":{"commonSideEffects":[{"rate":"10–30%","effect":"Injection site soreness or erythema"},{"rate":"5–15%","effect":"Myalgia"},{"rate":"5–10%","effect":"Headache"},{"rate":"1–5%","effect":"Fever"},{"rate":"5–10%","effect":"Fatigue"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The vaccine contains inactivated (killed) influenza virus particles representing three seasonal flu strains (typically two A subtypes and one B lineage). Upon administration, it triggers both humoral and cellular immune responses, leading to the production of neutralizing antibodies and memory B cells that protect against infection with matching or closely related circulating strains.","oneSentence":"Hualan TIV is a trivalent inactivated influenza vaccine that stimulates the immune system to produce antibodies against three strains of influenza virus.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:23:19.915Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Seasonal influenza prevention in adults and children"}]},"trialDetails":[{"nctId":"NCT05645900","phase":"PHASE3","title":"A Clinical Trial of an Quadrivalent Influenza Virus Subunit Vaccine in Chinese Children Aged 6 to 35 Months","status":"COMPLETED","sponsor":"Ab&B Bio-tech Co., Ltd.JS","startDate":"2023-02-06","conditions":"Influenza","enrollment":2772},{"nctId":"NCT05642078","phase":"PHASE3","title":"Phase Ⅲ Clinical Study of Quadrivalent Influenza Virus Split Vaccine","status":"COMPLETED","sponsor":"Anhui Zhifei Longcom Biologic Pharmacy Co., Ltd.","startDate":"2023-02-18","conditions":"Prevention of Influenza","enrollment":2550},{"nctId":"NCT03344029","phase":"PHASE4","title":"Immunogenicity and Safety of the Shenzhen Trivalent Inactivated Influenza Vaccine Versus a Trivalent Influenza Vaccine Comparator in Chinese Subjects 18 to 59 Years","status":"COMPLETED","sponsor":"Sanofi","startDate":"2017-11-03","conditions":"Influenza, Flu","enrollment":1600},{"nctId":"NCT01554826","phase":"PHASE3","title":"Clinical Trial of the Inactivated Influenza Vaccine (0.25ml Formulation for Pediatric Use)","status":"COMPLETED","sponsor":"Hualan Biological Engineering, Inc.","startDate":"2009-03","conditions":"Influenza","enrollment":810},{"nctId":"NCT01554813","phase":"PHASE3","title":"Clinical Trial of Inactivated Influenza Vaccine (0.5ml Formulation)","status":"COMPLETED","sponsor":"Hualan Biological Engineering, Inc.","startDate":"2006-05","conditions":"Influenza","enrollment":900},{"nctId":"NCT01511744","phase":"PHASE4","title":"Phase IV Clinical Trial of an Inactivated Influenza Split Vaccine","status":"COMPLETED","sponsor":"Hualan Biological Engineering, Inc.","startDate":"2011-11","conditions":"Human Influenza","enrollment":6000},{"nctId":"NCT01568788","phase":"NA","title":"Post-marketing Clinical Observation of an Inactivated Influenza Split Vaccine","status":"COMPLETED","sponsor":"Hualan Biological Engineering, Inc.","startDate":"2008-12","conditions":"Human Influenza","enrollment":600}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Hualan Trivalent Influenza Vaccine"],"phase":"marketed","status":"active","brandName":"Hualan TIV","genericName":"Hualan TIV","companyName":"Sanofi","companyId":"sanofi","modality":"Biologic","firstApprovalDate":"","aiSummary":"Hualan TIV is a trivalent inactivated influenza vaccine that stimulates the immune system to produce antibodies against three strains of influenza virus. Used for Seasonal influenza prevention in adults and children.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}