{"id":"hss-3","safety":{"commonSideEffects":[{"rate":null,"effect":"Hyperchloremic acidosis"},{"rate":null,"effect":"Hypernatremia"},{"rate":null,"effect":"Phlebitis at infusion site"},{"rate":null,"effect":"Renal dysfunction"}]},"_chembl":{"chemblId":"CHEMBL1835901","moleculeType":"Small molecule","molecularWeight":"298.34"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Hypertonic saline (3% sodium chloride) creates an osmotic gradient that pulls interstitial and intracellular fluid into the intravascular compartment, thereby reducing brain swelling and intracranial pressure. This mechanism is particularly useful in acute neurological emergencies where rapid reduction of cerebral edema is critical. The solution also has anti-inflammatory properties that may contribute to neuroprotection.","oneSentence":"HSS 3% is a hypertonic saline solution that draws fluid from tissues into the vascular space through osmotic gradient, reducing intracranial pressure and cerebral edema.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:46:11.964Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute intracranial hypertension and cerebral edema"},{"name":"Traumatic brain injury"},{"name":"Stroke with cerebral swelling"}]},"trialDetails":[{"nctId":"NCT02716246","phase":"PHASE2, PHASE3","title":"Phase I/II/III Gene Transfer Clinical Trial of scAAV9.U1a.hSGSH","status":"RECRUITING","sponsor":"Ultragenyx Pharmaceutical Inc","startDate":"2016-04-25","conditions":"MPS IIIA, Sanfilippo Syndrome, Sanfilippo A","enrollment":36},{"nctId":"NCT05782335","phase":"","title":"Analysis of T and B Cell Repertoire Changes in Response to Orencia® (Abatacept) in Rheumatoid 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Bacal","startDate":"2023-11-08","conditions":"Heart Transplantation, Acute Kidney Injury","enrollment":74},{"nctId":"NCT03750136","phase":"NA","title":"Furosemide Alone or Unexpectedly With Solution of Hypertonic Saline in Nephrotic Syndrome","status":"UNKNOWN","sponsor":"Medical University of Bialystok","startDate":"2018-12-15","conditions":"Nephrotic Syndrome","enrollment":30},{"nctId":"NCT04785755","phase":"PHASE2","title":"Effects of Adding Hypertonic Saline Solutions and/or Etilefrine to Standard Diuretics Therapy in Hepatic Ascites","status":"COMPLETED","sponsor":"Hala Abd EL-Tawab Ibrahim Radwan","startDate":"2017-11-30","conditions":"Hepatic Ascites","enrollment":90},{"nctId":"NCT03550651","phase":"NA","title":"Evaluation of Antiplaque Efficacy of Licorice Extract Mouthrinse & HSS and Their Comparison With EO & CHX Mouthrinse","status":"COMPLETED","sponsor":"Government College of Dentistry, Indore","startDate":"2016-08","conditions":"Mild Gingivitis, Periodontal Diseases, 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Bronchiolitis","enrollment":75}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":15,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"HSS 3%","genericName":"HSS 3%","companyName":"Ministry of Health, Spain","companyId":"ministry-of-health-spain","modality":"Small molecule","firstApprovalDate":"","aiSummary":"HSS 3% is a hypertonic saline solution that draws fluid from tissues into the vascular space through osmotic gradient, reducing intracranial pressure and cerebral edema. 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