{"id":"hrv-liquid","safety":{"commonSideEffects":[{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Irritability"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The vaccine contains weakened live rotavirus strains that replicate in the intestinal tract, stimulating both mucosal and systemic immune responses. This generates protective antibodies and cellular immunity against rotavirus without causing severe disease, thereby preventing infection or reducing severity of rotavirus-induced diarrhea and dehydration in infants and young children.","oneSentence":"HRV Liquid is a live attenuated human rotavirus vaccine administered orally to prevent rotavirus gastroenteritis.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:47:58.030Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of rotavirus gastroenteritis in infants and young children"}]},"trialDetails":[{"nctId":"NCT06331156","phase":"PHASE3","title":"A Study on the Immune Response and Safety of Inactivated Poliovirus Vaccine (IPV) When Co-administered With Human Rotavirus (HRV) Porcine Circovirus (PCV)-Free Vaccine in Healthy Chinese Infants","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2024-03-22","conditions":"Gastroenteritis","enrollment":400},{"nctId":"NCT06989242","phase":"NA","title":"Yoga-based, Movement Therapy Device as Noninvasive Glymphatic Clearance Augmentation in Alzheimer's Disease.","status":"NOT_YET_RECRUITING","sponsor":"CIATRIX, INC.","startDate":"2025-07-01","conditions":"Alzheimer Disease, Mild Cognitive Impairment (MCI)","enrollment":60},{"nctId":"NCT06025695","phase":"PHASE3","title":"Immunogenicity, Reactogenicity and Safety of GlaxoSmithKline (GSK) Biologicals' Rotarix Porcine Circovirus (PCV)-Free Liquid Compared to Rotarix Liquid Given in 2-doses in Healthy Chinese Infants Starting at Age 6-16 Weeks","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2023-09-01","conditions":"Gastroenteritis","enrollment":2000},{"nctId":"NCT03954743","phase":"PHASE3","title":"Safety Study of 2 Formulations of GSK's Human Rotavirus (HRV) Vaccine (444563), in Healthy Infants Starting at Age 6-12 Weeks","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2019-07-19","conditions":"Infections, Rotavirus","enrollment":1351},{"nctId":"NCT04851080","phase":"","title":"Medico-ecological Monitoring ((CSM, MCTQ, SPAQ, PSQI, HRV, Spirometry; Anthropometry, BP) of the Different Population Groups (Students, Schoolchildren, Volunteers) in North Caucasus","status":"UNKNOWN","sponsor":"Vladikavkaz Scientific Center of the Russian Academy of Sciences","startDate":"2019-04-01","conditions":"Conditionally Healthy Persons, Persons With a High Body Mass Index","enrollment":370},{"nctId":"NCT03207750","phase":"PHASE3","title":"This Study Will Evaluate the Immunogenicity, Reactogenicity and Safety of the Routine Infant Vaccines Pediarix®, Hiberix® and Prevenar 13® When Co-administered With GlaxoSmithKline (GSK) Biologicals' Liquid Human Rotavirus Vaccine (HRV) as Compared to GSK's Licensed Lyophilized Vaccine","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2017-09-14","conditions":"Rotavirus Infection, Rotavirus Vaccines","enrollment":1280},{"nctId":"NCT02141204","phase":"PHASE3","title":"Immunogenicity, Reactogenicity and Safety Study of Two Different Formulations of GSK Biologicals' Human Rotavirus Vaccine, Rotarix, in Healthy Infants","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2019-02-20","conditions":"Rotavirus","enrollment":451},{"nctId":"NCT02914184","phase":"PHASE3","title":"Evaluation of Immunogenicity and Safety of Two Formulations of GSK Biologicals' Human Rotavirus (HRV) Vaccine (444563), in Healthy Infants Starting at Age 6-12 Weeks","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2016-10-27","conditions":"Infections, Rotavirus, Rotavirus Vaccines","enrollment":1612},{"nctId":"NCT00750893","phase":"","title":"Evaluation of Reactogenicity and Safety of GSK Biologicals' Rotarix (Human Rotavirus Vaccine) in Infants","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2008-09-02","conditions":"Infections, Rotavirus","enrollment":3111},{"nctId":"NCT00432380","phase":"PHASE2","title":"A Study to Evaluate Immune Response and Safety of Two Doses of GSK Biologicals' HRV Liquid Vaccine in Healthy Infants.","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2007-03-09","conditions":"Infections, Rotavirus, Rotavirus Vaccines","enrollment":375},{"nctId":"NCT02907216","phase":"PHASE4","title":"Evaluation of Immunogenicity and Safety of the Diphtheria, Tetanus, Pertussis and Inactivated Poliovirus (DPT-IPV) Vaccine Squarekids Co-administered With GSK Biologicals' Human Rotavirus (HRV) Vaccine Rotarix (GSK444563) in Healthy Infants","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2016-09-16","conditions":"Rotavirus","enrollment":292},{"nctId":"NCT00420316","phase":"PHASE3","title":"Long-term Efficacy and Safety of Subjects Approximately 3 Years After Priming With 2 Doses of GSK Bio's HRV Vaccine.","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2007-02-12","conditions":"Infections, Rotavirus","enrollment":1613},{"nctId":"NCT01171963","phase":"PHASE3","title":"Study to Assess the Efficacy, Immunogenicity and Safety of Liquid Human Rotavirus Vaccine, in Healthy Chinese Infants","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2010-08-29","conditions":"Infections, Rotavirus","enrollment":3340},{"nctId":"NCT00363545","phase":"PHASE3","title":"To Assess Immunogenicity, Reactogenicity & Safety of 2 Formulations of GSK's HRV Vaccine as 2-dose Vaccination (Infants)","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2006-09-01","conditions":"Infections, Rotavirus","enrollment":1274},{"nctId":"NCT01107587","phase":"PHASE1","title":"Study to Assess the Safety of GSK Biologicals' Liquid Human Rotavirus Vaccine in Healthy Infants","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2010-04-13","conditions":"Infections, Rotavirus","enrollment":50},{"nctId":"NCT00382772","phase":"PHASE3","title":"A Study in Infants to Test Two Preparations (Freeze-dried or Liquid) of the Rotavirus Vaccine (HRV Vaccine).","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2006-11","conditions":"Infections, Rotavirus","enrollment":1200},{"nctId":"NCT00345956","phase":"PHASE3","title":"To Evaluate Immunogenicity, Reactogenicity & Safety of 2 Doses of GSK Bio HRV Liquid Vaccine Given to Infants (Vietnam)","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2006-09","conditions":"Infections, Rotavirus","enrollment":375}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":74,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"HRV Liquid","genericName":"HRV Liquid","companyName":"GlaxoSmithKline","companyId":"gsk","modality":"Biologic","firstApprovalDate":"","aiSummary":"HRV Liquid is a live attenuated human rotavirus vaccine administered orally to prevent rotavirus gastroenteritis. Used for Prevention of rotavirus gastroenteritis in infants and young children.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}