{"id":"hrs-8427","safety":{"commonSideEffects":[]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"HRS-8427 is an investigational small-molecule tyrosine kinase inhibitor developed by Jiangsu HengRui Medicine. While the precise molecular targets have not been widely disclosed in public literature, it is being evaluated in Phase 3 clinical trials for cancer indications. The drug is designed to inhibit aberrant kinase signaling that drives tumor growth and progression.","oneSentence":"HRS-8427 is a tyrosine kinase inhibitor that targets specific oncogenic pathways in cancer cells.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:45:49.984Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cancer (specific indication under Phase 3 evaluation)"}]},"trialDetails":[{"nctId":"NCT07049107","phase":"PHASE1","title":"Pharmacokinetics Impact of HRS-8427 on Bupropion and Midazolam in Healthy Subjects","status":"COMPLETED","sponsor":"Jiangsu HengRui Medicine Co., Ltd.","startDate":"2025-06-23","conditions":"Health Volunteer","enrollment":14},{"nctId":"NCT07073157","phase":"PHASE1","title":"Effect of HRS-8427 for Injection on the Pharmacokinetics of Furosemide and Metformin in Healthy Subjects。","status":"COMPLETED","sponsor":"Jiangsu HengRui Medicine Co., Ltd.","startDate":"2025-07-15","conditions":"Health Volunteer","enrollment":24},{"nctId":"NCT07070375","phase":"PHASE1","title":"Pharmacokinetics and Safety of HRS-8427 in Healthy Volunteers and in Patients With Impaired Renal Function","status":"COMPLETED","sponsor":"Jiangsu HengRui Medicine Co., Ltd.","startDate":"2023-04-19","conditions":"Gram-negative Bacterial Infections","enrollment":33},{"nctId":"NCT07049562","phase":"PHASE1","title":"Study on the Mass Balance of [14C]HRS-8427 for Injection in Healthy Chinese Subjects","status":"COMPLETED","sponsor":"Jiangsu HengRui Medicine Co., Ltd.","startDate":"2025-05-21","conditions":"Healthy Cninese Adult Male","enrollment":6},{"nctId":"NCT06841731","phase":"PHASE2","title":"A Trial of HRS-8427 in the Treatment of Adults With Bacterial Pneumonia","status":"RECRUITING","sponsor":"Jiangsu HengRui Medicine Co., Ltd.","startDate":"2025-04-03","conditions":"Hospital-acquired Bacterial Pneumonia (HABP), Ventilator-associated Bacterial Pneumonia (VABP)","enrollment":100},{"nctId":"NCT06569056","phase":"PHASE3","title":"A Trial of HRS-8427 in the Treatment of Adults With Complicated Urinary Tract Infection, Including Acute Pyelonephritis","status":"RECRUITING","sponsor":"Jiangsu HengRui Medicine Co., Ltd.","startDate":"2024-09-25","conditions":"Complicated Urinary Tract Infection(cUTI), Including Acute Pyelonephritis(AP)","enrollment":578},{"nctId":"NCT06144060","phase":"PHASE2","title":"A Trial of Intravenous HRS-8427 in the Treatment of Adults With Complicate Urinary Tract Infection, Including Acute Pyelonephritis","status":"UNKNOWN","sponsor":"Jiangsu HengRui Medicine Co., Ltd.","startDate":"2023-12","conditions":"Patients With Complicated Urinary Tract Infection(cUTI), Including Acute Pyelonephritis(AP)","enrollment":126}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"HRS-8427","genericName":"HRS-8427","companyName":"Jiangsu HengRui Medicine Co., Ltd.","companyId":"jiangsu-hengrui-medicine-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"HRS-8427 is a tyrosine kinase inhibitor that targets specific oncogenic pathways in cancer cells. Used for Cancer (specific indication under Phase 3 evaluation).","enrichmentLevel":3,"visitCount":2,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}