{"id":"hr20013-for-injection-dexamethasone","safety":{"commonSideEffects":[{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Insomnia"},{"rate":null,"effect":"Mood changes (euphoria, depression)"},{"rate":null,"effect":"Immunosuppression / increased infection risk"},{"rate":null,"effect":"Osteoporosis (with chronic use)"},{"rate":null,"effect":"Gastrointestinal upset"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dexamethasone acts as a potent corticosteroid that inhibits phospholipase A2, reducing prostaglandin and leukotriene production, and suppresses T-cell and B-cell proliferation. It decreases capillary permeability and stabilizes lysosomal membranes, thereby reducing inflammatory cell migration and mediator release. The drug is commonly used for its anti-inflammatory and immunosuppressive properties across multiple therapeutic contexts.","oneSentence":"Dexamethasone is a synthetic glucocorticoid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:45:45.266Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Inflammatory and allergic conditions"},{"name":"Cerebral edema"},{"name":"Adrenocortical insufficiency"},{"name":"Shock (septic, anaphylactic)"},{"name":"Autoimmune disorders"}]},"trialDetails":[{"nctId":"NCT05509634","phase":"PHASE3","title":"Clinical Study of HR20013 for Injection in Patients With Malignant Solid Tumors","status":"COMPLETED","sponsor":"Fujian Shengdi Pharmaceutical Co., Ltd.","startDate":"2022-09-21","conditions":"Prevention of Nausea and Vomiting Caused by Highly Emetogenic Chemotherapy","enrollment":754},{"nctId":"NCT05465681","phase":"PHASE1","title":"Study of HR20013 for Injection in Patients With Malignant Solid Tumors","status":"COMPLETED","sponsor":"Fujian Shengdi Pharmaceutical Co., Ltd.","startDate":"2022-08-30","conditions":"Prevention of Nausea and Vomiting Caused by Highly Emetogenic Chemotherapy","enrollment":24}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"HR20013 for injection；dexamethasone","genericName":"HR20013 for injection；dexamethasone","companyName":"Fujian Shengdi Pharmaceutical Co., Ltd.","companyId":"fujian-shengdi-pharmaceutical-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dexamethasone is a synthetic glucocorticoid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors. Used for Inflammatory and allergic conditions, Cerebral edema, Adrenocortical insufficiency.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}