{"id":"hpa-ans-stimulation","safety":{"commonSideEffects":[]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The hypothalamic-pituitary-adrenal (HPA) axis is a central neuroendocrine system that regulates stress responses through release of corticotropin-releasing hormone, adrenocorticotropic hormone, and cortisol. Stimulation of this axis via ANS (autonomic nervous system) activation increases sympathetic tone and glucocorticoid secretion, which can modulate immune function, metabolism, and cardiovascular responses. This mechanism may be leveraged therapeutically in conditions where enhanced stress hormone signaling or sympathetic activation is beneficial.","oneSentence":"HPA stimulation activates the hypothalamic-pituitary-adrenal axis to enhance sympathetic nervous system activity and stress hormone release.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:33:07.663Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[]},"trialDetails":[{"nctId":"NCT02372110","phase":"PHASE4","title":"Disentangling Anxiety Sensitivity and Anxiety-induced Physiological Stress Response","status":"COMPLETED","sponsor":"University of Texas at Austin","startDate":"2015-03","conditions":"Anxiety","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["vivarin, cortef"],"phase":"marketed","status":"active","brandName":"HPA, ANS stimulation","genericName":"HPA, ANS stimulation","companyName":"University of Texas at Austin","companyId":"university-of-texas-at-austin","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Researchers have studied the effects of HPA and ANS stimulation on anxiety through clinical trials, comparing these interventions to a placebo. The HPA and ANS systems are protein-based, as indicated by their modality classification in ChEMBL.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}