{"id":"house-dust-mite-novo-helisen-depot","safety":{"commonSideEffects":[{"rate":null,"effect":"Local injection site reactions (erythema, swelling, pruritus)"},{"rate":null,"effect":"Systemic allergic reactions"},{"rate":null,"effect":"Anaphylaxis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This is an allergen immunotherapy (AIT) product containing standardized house dust mite allergen extract. It works by gradually exposing the immune system to increasing doses of the allergen, promoting immune tolerance through shift toward regulatory T cells and anti-inflammatory responses. The depot formulation provides sustained release to maintain therapeutic allergen levels.","oneSentence":"House dust mite allergen extract that desensitizes the immune system through repeated subcutaneous administration to reduce allergic responses.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:32:12.789Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"House dust mite allergy (allergic rhinitis and/or allergic asthma)"}]},"trialDetails":[{"nctId":"NCT07096440","phase":"","title":"Noninterventional Study on Tolerability and Safety of One Strength Updosing With Novo-Helisen Depot House Dust Mites","status":"NOT_YET_RECRUITING","sponsor":"Allergopharma GmbH & Co. KG","startDate":"2025-07-30","conditions":"Allergic Rhinitis Due to House Dust Mite, Allergic Conjunctivitis Due to Dermatophagoides Farinae, Allergic Conjunctivitis Due to Dermatophagoides Pteronyssinus","enrollment":105},{"nctId":"NCT06523478","phase":"NA","title":"Intratonsillar Immunotherapy for Allergic Rhinitis","status":"RECRUITING","sponsor":"Xu Yu","startDate":"2024-04-29","conditions":"Allergic Rhinitis","enrollment":120},{"nctId":"NCT00263549","phase":"PHASE4","title":"Safety and Efficacy of House Dust Mite Allergen Extract in the Treatment of Allergic Rhinoconjunctivitis","status":"COMPLETED","sponsor":"Allergopharma GmbH & Co. KG","startDate":"2002-09","conditions":"House Dust Mite Allergy","enrollment":""},{"nctId":"NCT00496574","phase":"PHASE4","title":"Evaluation of Efficacy of House Dust Mite Immunotherapy in Children With Bronchial Asthma","status":"UNKNOWN","sponsor":"Medical University of Lodz","startDate":"2006-05","conditions":"Asthma","enrollment":60},{"nctId":"NCT00540150","phase":"PHASE3","title":"Compatibility and Immunogenicity of a Short Specific Immunotherapy (SIT) in Contrast to Classic Specific Immunotherapy","status":"COMPLETED","sponsor":"Johann Wolfgang Goethe University Hospital","startDate":"2004-05","conditions":"Immunotherapy","enrollment":34}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"House dust mite Novo Helisen Depot","genericName":"House dust mite Novo Helisen Depot","companyName":"Allergopharma GmbH & Co. KG","companyId":"allergopharma-gmbh-co-kg","modality":"Biologic","firstApprovalDate":"","aiSummary":"House dust mite allergen extract that desensitizes the immune system through repeated subcutaneous administration to reduce allergic responses. Used for House dust mite allergy (allergic rhinitis and/or allergic asthma).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}