{"id":"hormone-replacement-therapy","safety":{"commonSideEffects":[{"rate":"10–20%","effect":"Breast tenderness"},{"rate":"5–15%","effect":"Vaginal bleeding or spotting"},{"rate":"5–10%","effect":"Headache"},{"rate":"5–10%","effect":"Nausea"},{"rate":"1–3%","effect":"Venous thromboembolism (VTE)"},{"rate":"increased relative risk with prolonged use","effect":"Breast cancer (long-term use)"},{"rate":"increased with age and duration","effect":"Stroke"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"HRT works by restoring circulating levels of hormones that decline naturally with age or due to surgical/medical intervention. In menopausal women, exogenous estrogen and progestin bind to estrogen and progesterone receptors throughout the body, reducing vasomotor symptoms, improving bone density, and addressing genitourinary and mood-related symptoms. The specific formulation and route of administration determine tissue distribution and systemic exposure.","oneSentence":"Hormone replacement therapy supplements deficient endogenous hormones (typically estrogen and/or progesterone) to alleviate symptoms of hormonal imbalance or deficiency.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:32:12.645Z","_scrapedBy":"cloudflare-swarm","_wikipedia":{"url":"https://en.wikipedia.org/wiki/Hormone_replacement_therapy","title":"Hormone replacement therapy","extract":"Hormone replacement therapy (HRT), also known as menopausal hormone therapy or postmenopausal hormone therapy, is a form of hormone therapy used to treat symptoms associated with female menopause. Effects of menopause can include symptoms such as hot flashes, accelerated skin aging, vaginal dryness, decreased muscle mass, and complications such as osteoporosis, sexual dysfunction, and vaginal atrophy. They are mostly caused by low levels of female sex hormones that occur during menopause."},"indications":{"approved":[{"name":"Menopausal vasomotor symptoms (hot flashes, night sweats)"},{"name":"Genitourinary atrophy and sexual dysfunction"},{"name":"Osteoporosis prevention in postmenopausal women"},{"name":"Mood and cognitive symptoms associated with menopause"}]},"trialDetails":[{"nctId":"NCT02262806","phase":"PHASE2","title":"Compassionate Use of Metreleptin in Previously Treated People With Partial Lipodystrophy","status":"ACTIVE_NOT_RECRUITING","sponsor":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","startDate":"2014-10-14","conditions":"Diabetes, Lipodystrophy, Hyperlipidemia","enrollment":29},{"nctId":"NCT03569891","phase":"PHASE3","title":"HOPE-B: Trial of AMT-061 in Severe or Moderately Severe Hemophilia B Patients","status":"COMPLETED","sponsor":"CSL Behring","startDate":"2018-06-27","conditions":"Hemophilia B","enrollment":67},{"nctId":"NCT01303146","phase":"PHASE2","title":"Efficacy METAZYM for the Treatment Metachromatic Leukodystrophy Treated With Hematopoietic Stem Cell Transplantation","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2008-10","conditions":"Metachromatic Leukodystrophy","enrollment":1},{"nctId":"NCT07496294","phase":"NA","title":"Comparison of Oral Dydrogesterone and Vaginal Progesterone in Menopausal Hormone Therapy","status":"NOT_YET_RECRUITING","sponsor":"Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital","startDate":"2026-04","conditions":"Menopausal Women, Menopausal Symptom Relief, Hormone Therapy","enrollment":200},{"nctId":"NCT06972719","phase":"NA","title":"Hormone Replacement Therapy After Risk Reducing Salpingo-oophorectomy","status":"RECRUITING","sponsor":"Duke University","startDate":"2025-09-30","conditions":"BRCA1 Mutation, BRCA2 Mutation","enrollment":50},{"nctId":"NCT07270549","phase":"PHASE1, PHASE2","title":"Gene Replacement Therapy for Treatment of Paediatric Patients With CTNNB1 Neurodevelopmental Syndrome","status":"RECRUITING","sponsor":"CTNNB1 Foundation","startDate":"2025-11-01","conditions":"CTNNB1 Neurodevelopmental Syndrome","enrollment":12},{"nctId":"NCT07184866","phase":"NA","title":"Vitamin C for Acute Kidney Injury in ACLF With Septic Shock: A Randomized Controlled Trial","status":"NOT_YET_RECRUITING","sponsor":"Institute of Liver and Biliary Sciences, India","startDate":"2026-04","conditions":"Acute-on-Chronic Liver Failure (ACLF)","enrollment":110},{"nctId":"NCT07178366","phase":"NA","title":"Double Plasma Separation and Adsorption in Acute-on-Chronic Liver Failure (DPMAS-ACLF Trial)","status":"NOT_YET_RECRUITING","sponsor":"Institute of Liver and Biliary Sciences, India","startDate":"2026-05-10","conditions":"Acute-on-Chronic Liver Failure (ACLF)","enrollment":56},{"nctId":"NCT06136650","phase":"PHASE3","title":"A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)","status":"RECRUITING","sponsor":"Merck Sharp & Dohme LLC","startDate":"2023-12-18","conditions":"Metastatic Castration-resistant Prostate Cancer (mCRPC), Prostatic Neoplasms","enrollment":1314},{"nctId":"NCT06229990","phase":"PHASE4","title":"A Protocol Based-Furosemide Stress Test to Evaluate Renal Recovery During Continuous Renal Replacement Therapy","status":"RECRUITING","sponsor":"Chiang Mai University","startDate":"2024-01-01","conditions":"Acute Kidney Injury","enrollment":80},{"nctId":"NCT05758077","phase":"NA","title":"Neutrophil and Monocyte Deactivation Via the SeLective CytopheretIc Device - A Randomized Clinical Trial in Acute Kidney Injury","status":"RECRUITING","sponsor":"SeaStar Medical","startDate":"2023-04-17","conditions":"Acute Kidney Injury","enrollment":339},{"nctId":"NCT07123155","phase":"PHASE2","title":"Study of S-606001 as an Add-on to Enzyme Replacement Therapy (ERT) in Participants With Late-onset Pompe Disease (LOPD)","status":"RECRUITING","sponsor":"Shionogi","startDate":"2025-10-30","conditions":"Pompe Disease","enrollment":45},{"nctId":"NCT04082429","phase":"PHASE3","title":"Research Study to Look at How Well the Drug Concizumab Works in Your Body if You Have Haemophilia Without Inhibitors","status":"ACTIVE_NOT_RECRUITING","sponsor":"Novo Nordisk A/S","startDate":"2019-11-13","conditions":"Haemophilia A Without Inhibitors, Haemophilia B Without Inhibitors","enrollment":156},{"nctId":"NCT06851754","phase":"PHASE3","title":"Hormone Replacement Therapy in Adolescents With Premature Ovarian Insufficiency","status":"RECRUITING","sponsor":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","startDate":"2025-07-17","conditions":"Premature Ovarian Insufficiency","enrollment":185},{"nctId":"NCT05639010","phase":"NA","title":"Effects of Hemodialysis Plus Hemoperfusion in Maintenance Hemodialysis Patients: A Clinical Study","status":"ACTIVE_NOT_RECRUITING","sponsor":"Changhai Hospital","startDate":"2023-01-01","conditions":"End Stage Renal Disease","enrollment":410},{"nctId":"NCT07462663","phase":"","title":"SHAPE-ENDO: Multimodal Pre-Surgical Optimization in Patients With Obesity and Early-Stage Endometrial Cancer","status":"NOT_YET_RECRUITING","sponsor":"Hospital Universitari de Bellvitge","startDate":"2026-05","conditions":"Endometrial Cancer, Endometrial Cancer Stage I, Atypical Endometrial Hyperplasia and Endometrial Carcinoma Stage I","enrollment":82},{"nctId":"NCT07487818","phase":"PHASE2, PHASE3","title":"A Study Of Vagal Nerve Stimulation In Conjunction With NRT For Smoking Cessation","status":"NOT_YET_RECRUITING","sponsor":"Mayo Clinic","startDate":"2026-04-15","conditions":"Smoking Cessation","enrollment":150},{"nctId":"NCT05161078","phase":"","title":"Improving Continuous Renal Replacement Therapy Outcomes in Neonates and Infants Through Interdisciplinary Collaboration","status":"ENROLLING_BY_INVITATION","sponsor":"Children's Hospital Medical Center, Cincinnati","startDate":"2021-12-16","conditions":"Acute Kidney Injury, Chronic Kidney Diseases, Renal Dialysis","enrollment":1000},{"nctId":"NCT06517810","phase":"","title":"QUELIMMUNE (SCD-PED) PediAtric SurVeillance REgistry","status":"RECRUITING","sponsor":"SeaStar Medical","startDate":"2024-07-19","conditions":"Acute Kidney Injury, Acute Kidney Injury Due to Sepsis","enrollment":300},{"nctId":"NCT05515354","phase":"PHASE4","title":"Smoking Cessation and Menstrual Cycle Phase","status":"RECRUITING","sponsor":"Centre for Addiction and Mental Health","startDate":"2022-11-30","conditions":"Nicotine Dependence, Tobacco Smoking, Smoking Cessation","enrollment":1200},{"nctId":"NCT05473143","phase":"NA","title":"Proactive Prescription-based Fluid Management vs Usual Care in Critically Ill Patients on Kidney Replacement Therapy","status":"ACTIVE_NOT_RECRUITING","sponsor":"Centre hospitalier de l'Université de Montréal (CHUM)","startDate":"2023-04-03","conditions":"Acute Kidney Injury, Kidney Replacement, Critical Illness","enrollment":150},{"nctId":"NCT06667999","phase":"PHASE4","title":"The Intensive Care Platform Trial","status":"RECRUITING","sponsor":"Anders Perner","startDate":"2025-06-26","conditions":"Intensive Care Patients, Intensive Care Unit Patients, Critical Illness","enrollment":10000},{"nctId":"NCT05568459","phase":"","title":"A Trial That Evaluates Disease Characteristics in Hemophilia B Adult Male Participants Receiving Prophylaxis With Standard of Care Factor IX Protein (FIX) Replacement Therapy","status":"ACTIVE_NOT_RECRUITING","sponsor":"Regeneron Pharmaceuticals","startDate":"2024-01-17","conditions":"Hemophilia B","enrollment":11},{"nctId":"NCT07479238","phase":"","title":"Breath Test-Based Assessment of SIBO in Chronic Pancreatitis and Partial Pancreatectomy","status":"NOT_YET_RECRUITING","sponsor":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","startDate":"2026-03-15","conditions":"SIBO, Pancreatic Insufficiency, Chronic Pancreatitis","enrollment":100},{"nctId":"NCT04532047","phase":"PHASE1","title":"PEARL (PrEnAtal Enzyme Replacement Therapy for Lysosomal Storage Disorders)","status":"RECRUITING","sponsor":"University of California, San Francisco","startDate":"2021-07-01","conditions":"MPS I, MPS II, MPS IVA","enrollment":10},{"nctId":"NCT06446739","phase":"NA","title":"LoW Dose-Intensity vs. Standard Dose-Intensity COntinuous Renal ReplaceMent Therapy in Critically Ill Patients (WISDOM)","status":"RECRUITING","sponsor":"University of Alberta","startDate":"2024-11-14","conditions":"Acute Kidney Injury, Dialysis; Complications","enrollment":100},{"nctId":"NCT03249428","phase":"NA","title":"Cytisine vs Nicotine Replacement Therapy","status":"ENROLLING_BY_INVITATION","sponsor":"Ottawa Hospital Research Institute","startDate":"2025-11-04","conditions":"Tobacco Dependence, COPD Asthma, Mental Illness","enrollment":200},{"nctId":"NCT05186636","phase":"","title":"Dialyzing Wisely - Improving the Delivery of Acute Renal Replacement Therapy to Albertans","status":"RECRUITING","sponsor":"University of Alberta","startDate":"2023-01-12","conditions":"Acute Renal Injury","enrollment":4500},{"nctId":"NCT07474441","phase":"","title":"Early Coronary Angiography in Advanced Chronic Kidney Disease With Acute Coronary Syndrome","status":"COMPLETED","sponsor":"Chulalongkorn University","startDate":"2017-01-01","conditions":"CKD, ACS (Acute Coronary Syndrome), Coronary Angiography (CAG)","enrollment":139},{"nctId":"NCT04608149","phase":"","title":"Prospective, Multi-center, Single-arm, Observational Study. US FDA 522 Pediatric Post Market Surveillance Study.","status":"ACTIVE_NOT_RECRUITING","sponsor":"Medtronic - MITG","startDate":"2021-01-20","conditions":"Acute Kidney Injury, Fluid Overload","enrollment":36},{"nctId":"NCT07467889","phase":"","title":"Impact of CRRT on Serum Carnitine and Micronutrient Levels","status":"COMPLETED","sponsor":"Gulhane Training and Research Hospital","startDate":"2023-01-01","conditions":"Acute Kidney Injury (Nontraumatic), Critical Illness","enrollment":43},{"nctId":"NCT04794595","phase":"","title":"Clinical Features and Outcomes of CBP Versus Non-CBP in Septic Children","status":"RECRUITING","sponsor":"Children's Hospital of Fudan University","startDate":"2020-12-01","conditions":"Sepsis, Children, Only","enrollment":90},{"nctId":"NCT07474805","phase":"","title":"Outcomes of Renal Replacement in Mexico","status":"NOT_YET_RECRUITING","sponsor":"Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran","startDate":"2026-04","conditions":"Chronic Kidney Disease - Stage V, Chronic Kidney Disease on Hemodialysis","enrollment":290},{"nctId":"NCT05725421","phase":"NA","title":"Transplantation of Reconstructed Renal Allografts Following Ex-Vivo Partial Nephrectomy","status":"RECRUITING","sponsor":"Case Comprehensive Cancer Center","startDate":"2023-09-08","conditions":"Renal Cell Carcinoma","enrollment":5},{"nctId":"NCT06906367","phase":"","title":"A Study of Patients With Fabry Disease (US Specific)","status":"RECRUITING","sponsor":"Amicus Therapeutics","startDate":"2026-02-13","conditions":"Fabry Disease","enrollment":450},{"nctId":"NCT07469072","phase":"PHASE2","title":"Comparison of Anticoagulant Effects of Different Doses of Nafamostat in Continuous Renal Replacement Therapy (CRRT) in the Intensive Care Unit (ICU)","status":"NOT_YET_RECRUITING","sponsor":"Zhujiang Hospital","startDate":"2026-02-25","conditions":"Continuous Renal Replacement Therapy (CRRT)","enrollment":92},{"nctId":"NCT06945120","phase":"NA","title":"ACT Lung Health Intervention: Phase Two","status":"RECRUITING","sponsor":"Dana-Farber Cancer Institute","startDate":"2025-11-04","conditions":"Smoking Cessation, Smoking Behaviors, Smoking, Tobacco","enrollment":50},{"nctId":"NCT06811038","phase":"PHASE3","title":"iCanQuit Smoking Cessation Among Hispanic Adults","status":"NOT_YET_RECRUITING","sponsor":"Fred Hutchinson Cancer Center","startDate":"2026-04-01","conditions":"Cigarette Smoking-Related Carcinoma","enrollment":854},{"nctId":"NCT06966362","phase":"PHASE4","title":"Varenicline for Smoking Reduction in Veterans Not Ready To Quit","status":"NOT_YET_RECRUITING","sponsor":"VA Office of Research and Development","startDate":"2026-07-01","conditions":"Veterans, Tobacco Use Disorder, Cigarette Smoking","enrollment":400},{"nctId":"NCT07466875","phase":"NA","title":"Auricular Stimulation for Nicotine Withdrawal in Psychiatric Inpatients","status":"NOT_YET_RECRUITING","sponsor":"Chiao-Chiao Liao","startDate":"2026-04-01","conditions":"Nicotine Dependence, Nicotine Withdrawal, Tobacco Use Disorder","enrollment":60},{"nctId":"NCT07089901","phase":"PHASE4","title":"Project DEDUCE: Digital Envirotyping to Develop Understanding of Cigarette Smoking and the Environment","status":"NOT_YET_RECRUITING","sponsor":"Duke University","startDate":"2026-04-06","conditions":"Smoking","enrollment":600},{"nctId":"NCT05305781","phase":"","title":"Study of the Determinants of Emergency Dialysis in Reunion Island","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire de la Réunion","startDate":"2022-03-01","conditions":"Dialysis","enrollment":233},{"nctId":"NCT07262320","phase":"","title":"Epidemiology and Processes of Care for Renal Replacement Therapy in Acute Kidney Injury in Latin America","status":"RECRUITING","sponsor":"University of Alabama at Birmingham","startDate":"2026-03-01","conditions":"Dialysis, Critically Ill Acute Kidney Injury, Renal Replacement Therapy for Acute Kidney Injury in ICU","enrollment":1000},{"nctId":"NCT05722561","phase":"PHASE2","title":"E-Cigarettes for Harm Reduction in Smokers With Opioid Use Disorder","status":"RECRUITING","sponsor":"NYU Langone Health","startDate":"2024-08-08","conditions":"Opioid Use Disorder, Cigarette Smoking","enrollment":302},{"nctId":"NCT05787470","phase":"","title":"State of Hormones Impact Nociceptive Expression","status":"RECRUITING","sponsor":"University of Alabama at Birmingham","startDate":"2023-03-01","conditions":"Pain, Gender Identity","enrollment":120},{"nctId":"NCT06121011","phase":"","title":"A Global Prospective Observational Registry of Patients With Pompe Disease","status":"RECRUITING","sponsor":"Amicus Therapeutics","startDate":"2024-02-16","conditions":"Pompe Disease","enrollment":500},{"nctId":"NCT07024992","phase":"PHASE2","title":"Enhancing Smoking Cessation for African American People Everywhere","status":"NOT_YET_RECRUITING","sponsor":"University of Houston","startDate":"2026-04-01","conditions":"ESCAPE Intervention+NRT, quitSTART Intervention+NRT, CTRL+NRT","enrollment":300},{"nctId":"NCT07455773","phase":"NA","title":"Experimental Study on the Use of Intrauterine Infusion of Autologous Platelet-rich Plasma (PRGF-IUI) in Patients With Recurrent Implantation Failure and/or Refractory Thin Endometrium","status":"NOT_YET_RECRUITING","sponsor":"Azienda Sanitaria Locale di Asti","startDate":"2026-05-01","conditions":"Recurrent Implantation Failure, Endometrial Receptivity Disorders, Embryo Implantation","enrollment":80},{"nctId":"NCT04881630","phase":"NA","title":"Mobile Contingency Management for Smoking Cessation","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Oklahoma","startDate":"2022-11-08","conditions":"Smoking Cessation","enrollment":532},{"nctId":"NCT06832085","phase":"PHASE4","title":"Combination Nicotine Replacement Therapy, Cytisine, or Varenicline for Smoking Cessation","status":"RECRUITING","sponsor":"Ottawa Heart Institute Research Corporation","startDate":"2025-04-30","conditions":"Tobacco","enrollment":150},{"nctId":"NCT07447791","phase":"NA","title":"WISDOM UK: Low Dose-intensity Versus Standard Dose-intensity CRRT in Critically Ill Patients","status":"RECRUITING","sponsor":"Guy's and St Thomas' NHS Foundation Trust","startDate":"2025-02-15","conditions":"Acute Kidney Injury (Nontraumatic), Dialysis; Complications","enrollment":20},{"nctId":"NCT06744049","phase":"NA","title":"Transfer Direct System as a New Method for Embryo Transfer","status":"RECRUITING","sponsor":"Premium Fertility","startDate":"2024-10-21","conditions":"Embryo Transfer","enrollment":80},{"nctId":"NCT04138277","phase":"PHASE3","title":"A Study to Assess the Long-term Safety and Efficacy of ATB200/AT2221 in Adult Subjects With Late-Onset Pompe Disease (LOPD)","status":"COMPLETED","sponsor":"Amicus Therapeutics","startDate":"2019-12-18","conditions":"Pompe Disease (Late-onset)","enrollment":119},{"nctId":"NCT04002531","phase":"NA","title":"A One Visit Follow Up of Adults With Fabry Disease Who Started Long-term Enzyme Replacement Therapy As Children","status":"COMPLETED","sponsor":"Baylor Research Institute","startDate":"2018-11-10","conditions":"Quality of Life, Renal Insufficiency, Cardiac Event","enrollment":5},{"nctId":"NCT05679401","phase":"PHASE3","title":"A Study With Imlifidase in Anti-GBM Disease","status":"TERMINATED","sponsor":"Hansa Biopharma AB","startDate":"2022-12-22","conditions":"Anti-Glomerular Basement Membrane Disease, Anti-Glomerular Basement Membrane Antibody Disease, Goodpasture Syndrome","enrollment":50},{"nctId":"NCT06922617","phase":"NA","title":"STEPS: Substance Use Trial of E-cigarettes or Pharmacotherapy for Smoking","status":"RECRUITING","sponsor":"Medical University of South Carolina","startDate":"2025-10-17","conditions":"Tobacco Use, Substance Use Disorders","enrollment":240},{"nctId":"NCT07450300","phase":"","title":"Assessment of the Feasibility of Frozen Embryo Transfers in a Natural Cycle Among Obese Compared to Non-Obese Patients","status":"COMPLETED","sponsor":"Clinique Mathilde","startDate":"2022-11-01","conditions":"Infertility, Female","enrollment":1831},{"nctId":"NCT07447635","phase":"NA","title":"Testing an MBI for Smoking Cessation and Alcohol Use Among Cancer Survivors","status":"NOT_YET_RECRUITING","sponsor":"H. Lee Moffitt Cancer Center and Research Institute","startDate":"2026-02","conditions":"Smoking Cessation, Alcohol Use","enrollment":600},{"nctId":"NCT07447128","phase":"","title":"Prospective Analysis of Arteriovenous Access (AVA) Use for Continuous Renal Replacement Therapy (CRRT)","status":"NOT_YET_RECRUITING","sponsor":"East Carolina University","startDate":"2026-03","conditions":"Continuous Renal Replacement Therapy (CRRT), End Stage Kidney Disease (ESRD)","enrollment":50},{"nctId":"NCT05144542","phase":"NA","title":"Risk and Benefits of Electronic Cigarettes to Older Smokers at High Risk for Lung Cancer","status":"ACTIVE_NOT_RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2022-03-07","conditions":"Lung Carcinoma","enrollment":140},{"nctId":"NCT07081997","phase":"PHASE3","title":"A Phase 3 Randomized Clinical Trial to Investigate the Safety and Efficacy of Palopegteriparatide at Doses Greater Than 30 μg/Day in Adult Participants With Hypoparathyroidism","status":"NOT_YET_RECRUITING","sponsor":"Ascendis Pharma Bone Diseases A/S","startDate":"2026-04","conditions":"Hypoparathyroidism, Endocrine System Diseases, Parathyroid Diseases","enrollment":36},{"nctId":"NCT07441824","phase":"PHASE3","title":"Pancreatic Enzyme Replacement in Acute Necrotizing Pancreatitis","status":"NOT_YET_RECRUITING","sponsor":"Asian Institute of Gastroenterology, India","startDate":"2026-02","conditions":"Acute Necrotizing Pancreatitis, Pancreatic Exocrine Insufficiency","enrollment":140},{"nctId":"NCT07007195","phase":"EARLY_PHASE1","title":"Smart Olfaction App to Reduce Relapse","status":"NOT_YET_RECRUITING","sponsor":"University of Houston","startDate":"2026-03-23","conditions":"Nicotine Dependence","enrollment":132},{"nctId":"NCT04965181","phase":"NA","title":"Mindfulness-based Smoking Cessation Enhanced With Mobile Technology","status":"COMPLETED","sponsor":"Georgia State University","startDate":"2021-07-01","conditions":"Cigarette Smoking","enrollment":504},{"nctId":"NCT06078696","phase":"PHASE1, PHASE2","title":"Siplizumab for Sickle Cell Disease Transplant","status":"TERMINATED","sponsor":"Columbia University","startDate":"2023-09-28","conditions":"Anemia, Sickle Cell","enrollment":1},{"nctId":"NCT05030272","phase":"NA","title":"Comparing Two Behavioral Approaches to Quitting Smoking in Mental Health Settings","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2021-09-21","conditions":"Tobacco Use Disorder, Mental Illness, Recurring Major Depressive Disorder","enrollment":343},{"nctId":"NCT05192837","phase":"NA","title":"Preoperative Smoking Cessation in Patients Undergoing Surgery","status":"TERMINATED","sponsor":"Luzerner Kantonsspital","startDate":"2022-09-02","conditions":"Smoking Cessation, Smoking Reduction, Surgery--Complications","enrollment":251},{"nctId":"NCT07436793","phase":"PHASE2","title":"Progestins for the Treatment of Endometrial Cancer or Precancers of the Uterus Before Surgery, The Pro-Window Trial","status":"NOT_YET_RECRUITING","sponsor":"New Mexico Cancer Research Alliance","startDate":"2026-03-01","conditions":"Endometrial Endometrioid Adenocarcinoma, Endometrial Hyperplasia","enrollment":140},{"nctId":"NCT06839729","phase":"PHASE1","title":"Addressing Parental Tobacco Use in Somali Immigrant Families: Adapting an Evidence-Based Intervention in Primary Care","status":"NOT_YET_RECRUITING","sponsor":"University of Minnesota","startDate":"2027-01-01","conditions":"Smoking, Smoking Cessation","enrollment":50},{"nctId":"NCT07025772","phase":"NA","title":"Shaping Habitual Impulses For a Tobacco-free Style","status":"NOT_YET_RECRUITING","sponsor":"University of Houston","startDate":"2026-03-09","conditions":"ST+ABR, ST+SHAM, ST-only","enrollment":300},{"nctId":"NCT05642962","phase":"PHASE1, PHASE2","title":"Pancrelipase in People With Pancreatic Ductal Adenocarcinoma (PDAC)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Memorial Sloan Kettering Cancer Center","startDate":"2022-11-30","conditions":"Metastatic Pancreatic Ductal Adenocarcinoma, Metastatic Pancreatic Cancer, Metastatic Pancreatic Adenocarcinoma","enrollment":17},{"nctId":"NCT04798664","phase":"NA","title":"Comparing Smoking Cessation Interventions Among Underserved Patients Referred for Lung Cancer Screening","status":"COMPLETED","sponsor":"Abramson Cancer Center at Penn Medicine","startDate":"2021-05-17","conditions":"Smoking Cessation","enrollment":3228},{"nctId":"NCT07204080","phase":"PHASE2","title":"(TNX-1500) in Kidney Transplant Recipients","status":"NOT_YET_RECRUITING","sponsor":"Ayman Al Jurdi, MD","startDate":"2026-07-01","conditions":"Kidney Transplant, Kidney Transplant Failure and Rejection, Immunosuppression","enrollment":5},{"nctId":"NCT06860243","phase":"PHASE1","title":"A Study to Evaluate Opevesostat (MK-5684) in Male Participants With Moderate Hepatic Impairment (MK-5684-009)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2025-05-13","conditions":"Hepatic Impairment, Healthy Participants","enrollment":16},{"nctId":"NCT07428395","phase":"","title":"Feasibility of Intradialytic Monitoring During CKRT","status":"NOT_YET_RECRUITING","sponsor":"University of Pennsylvania","startDate":"2026-03","conditions":"Acute Kidney Injury, End Stage Chronic Renal Failure, Dialysis","enrollment":30},{"nctId":"NCT07278973","phase":"NA","title":"Hemodiafiltration Versus Hemodialysis in Older People","status":"RECRUITING","sponsor":"AUB Santé","startDate":"2026-02-19","conditions":"Hemodialysis, Hemodiafiltration, Fatigue Symptom","enrollment":62},{"nctId":"NCT07278362","phase":"PHASE4","title":"Testosterone Replacement Therapy in Hypogonadal Patients With Prostate Cancer Under Active Surveillance","status":"NOT_YET_RECRUITING","sponsor":"University of Miami","startDate":"2026-05-31","conditions":"Prostate Cancer, Hypogonadism, Male","enrollment":35},{"nctId":"NCT07426575","phase":"","title":"Evaluating the Usability of New Dialysis Bags","status":"NOT_YET_RECRUITING","sponsor":"Erasmus Medical Center","startDate":"2026-02-15","conditions":"Renal Replacement Therapies","enrollment":126},{"nctId":"NCT07419802","phase":"","title":"OxiCLEAR (Oxiris Cytokines and Endotoxin Adsorption Rate) Study","status":"RECRUITING","sponsor":"Pauls Stradins Clinical University Hospital","startDate":"2026-03-01","conditions":"Sepsis, Septic Shock, Blood Purification","enrollment":29},{"nctId":"NCT05712421","phase":"PHASE2","title":"A Study Evaluation the Safety and Efficacy of Hormone Replacement Therapy With North Star Compared to Levothyroxine in Patients With Primary Hypothyroidism","status":"COMPLETED","sponsor":"Neuvosyn Laboratories, LLC","startDate":"2023-02-28","conditions":"Hypothyroidism","enrollment":303},{"nctId":"NCT07418593","phase":"PHASE4","title":"THE MALABSORPTION BLOOD TEST TRIAL WILL HELP DETERMINE THE BENEFITS OF PANCREATIC ENZYME REPLACEMENT THERAPY IN PATIENTS WITH MILD TO MODERATE EXOCRINE PANCREATIC INSUFFICIENCY.","status":"RECRUITING","sponsor":"Anna Evans Phillips","startDate":"2026-03","conditions":"Chronic Pancreatitis, Recurrent Acute Pancreatitis, Exocrine Pancreatic Insufficiency","enrollment":80},{"nctId":"NCT05723588","phase":"PHASE2","title":"Neuroimaging Correlates and Feasibility of Transcranial Magnetic Stimulation (TMS) to Improve Smoking Cessation Outcomes in Veterans With Comorbid PTSD","status":"RECRUITING","sponsor":"VA Office of Research and Development","startDate":"2023-10-31","conditions":"Tobacco Use Disorder","enrollment":50},{"nctId":"NCT07416578","phase":"NA","title":"Clinical Study on the Effect of Umbilical Cord Mesenchymal Stem Cell Exosomes on Endometrial Repair of Intrauterine Adhesions","status":"ACTIVE_NOT_RECRUITING","sponsor":"Sixth Affiliated Hospital, Sun Yat-sen University","startDate":"2026-01-01","conditions":"Intrauterine Adhesions, Exosomes","enrollment":60},{"nctId":"NCT06290869","phase":"PHASE3","title":"Tobacco Education and Lung Health Study (TEAL)","status":"RECRUITING","sponsor":"Georgetown University","startDate":"2024-02-22","conditions":"Smoking Cessation","enrollment":1188},{"nctId":"NCT07099638","phase":"PHASE2","title":"Trial of Varenicline With Nicotine Lozenges and a Smartphone Medication Adherence Intervention for Smoking Cessation","status":"NOT_YET_RECRUITING","sponsor":"University of Oklahoma","startDate":"2026-03","conditions":"Smoking Cessation","enrollment":496},{"nctId":"NCT07326215","phase":"NA","title":"A Study of the Efficacy and Safety of Extracorporeal Carbon Dioxide Removal Using PrismaLung+","status":"RECRUITING","sponsor":"Vantive Health LLC","startDate":"2025-12-11","conditions":"Acute Respiratory Distress Syndrome, Acute Kidney Injury","enrollment":99},{"nctId":"NCT04525755","phase":"PHASE1, PHASE2","title":"STARS (Smoking Treatment And Remote Sampling) Study","status":"COMPLETED","sponsor":"Medical University of South Carolina","startDate":"2021-02-08","conditions":"Smoking, Smoking Cessation, Tobacco Smoking","enrollment":652},{"nctId":"NCT07412717","phase":"NA","title":"The Efficacy of Combining Music Intervention With Nicotine Replacement Therapy to Reduce Smoking Craving, Among Healthcare Professionals Who Are Trying to Quit.","status":"NOT_YET_RECRUITING","sponsor":"Poitiers University Hospital","startDate":"2026-03-01","conditions":"Nicotine Replacement Therapy, Healthcare Professionals, Tobacco Craving","enrollment":80},{"nctId":"NCT06633029","phase":"","title":"Retrospective Analysis of Prismaflex HF20 Set Versus ppCRRT Registry","status":"COMPLETED","sponsor":"Vantive Health LLC","startDate":"2024-12-11","conditions":"Acute Renal Failure (ARF), Acute Kidney Injury (AKI), Fluid Overload in Dialysis Patients","enrollment":59},{"nctId":"NCT05214729","phase":"NA","title":"A Net Ultrafiltration Challenge to Predict Preload-dependence (UF CHALLENGE)","status":"COMPLETED","sponsor":"Hospices Civils de Lyon","startDate":"2022-07-14","conditions":"Acute Kidney Injury","enrollment":20},{"nctId":"NCT05175053","phase":"NA","title":"Early RRT in AKI After Cardiac Surgery","status":"TERMINATED","sponsor":"Seoul National University Hospital","startDate":"2021-12-24","conditions":"Acute Kidney Injury","enrollment":44},{"nctId":"NCT07406412","phase":"","title":"Hormonal Regulation of Cardiometabolic Health Study","status":"NOT_YET_RECRUITING","sponsor":"University of Jyvaskyla","startDate":"2026-02-20","conditions":"Menopause Surgical","enrollment":120},{"nctId":"NCT05790486","phase":"NA","title":"Take A Break - Rural","status":"RECRUITING","sponsor":"Wake Forest University Health Sciences","startDate":"2023-07-11","conditions":"Smoking, Smoking Behaviors, Smoking Cessation","enrollment":800},{"nctId":"NCT06173778","phase":"PHASE2","title":"Semaglutide for Post-Smoking Cessation Weight Management","status":"RECRUITING","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2024-04-23","conditions":"Obesity, Overweight, Cigarette Smoking","enrollment":197},{"nctId":"NCT04731376","phase":"PHASE1","title":"Perioperative Testosterone Replacement Therapy for the Improvement of Post-Operative Outcomes in Patients With Low Testosterone","status":"ACTIVE_NOT_RECRUITING","sponsor":"Emory University","startDate":"2021-01-25","conditions":"Hypogonadism, Malignant Urinary System Neoplasm, Urinary System Disorder","enrollment":56},{"nctId":"NCT07388797","phase":"","title":"Impact of Serum Progesterone Levels on Embryo Transfer Day on Clinical Pregnancy","status":"NOT_YET_RECRUITING","sponsor":"Chinese University of Hong Kong","startDate":"2026-02-10","conditions":"Reproductive Issues","enrollment":370},{"nctId":"NCT06647602","phase":"","title":"Thyroid Hormone Replacement After Radio Iodine: Value and Efficacy","status":"NOT_YET_RECRUITING","sponsor":"University Medical Center Groningen","startDate":"2026-09-01","conditions":"Differentiated Thyroid Cancer, Thyroid Cancer, Levothyroxine","enrollment":40},{"nctId":"NCT07394049","phase":"","title":"Impact of New Hormone Replacement Therapy After Menopause on Heart Health in Women","status":"NOT_YET_RECRUITING","sponsor":"Heinrich-Heine University, Duesseldorf","startDate":"2026-03-01","conditions":"Hormone Replacement Therapy, Cardiovascular Diseases, Hormone Replacement Therapy, Post-Menopausal","enrollment":2725},{"nctId":"NCT02162849","phase":"PHASE4","title":"Reward Sensitivity and Pharmacotherapy for Smoking Cessation","status":"ACTIVE_NOT_RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2015-12-14","conditions":"Tobacco Use Cessation","enrollment":204},{"nctId":"NCT06733350","phase":"PHASE4","title":"Testosterone Replacement Therapy for the Treatment of Low Testosterone in Hypogonadal Men With Localized Prostate Cancer on Active Surveillance","status":"SUSPENDED","sponsor":"Roswell Park Cancer Institute","startDate":"2025-01-15","conditions":"Localized Prostate Carcinoma, Stage I Prostate Cancer AJCC v8, Stage II Prostate Cancer AJCC v8","enrollment":600}],"_emaApprovals":[],"_faersSignals":[{"count":1010,"reaction":"BREAST CANCER FEMALE"},{"count":51,"reaction":"DRUG INEFFECTIVE"},{"count":41,"reaction":"HEADACHE"},{"count":41,"reaction":"NAUSEA"},{"count":40,"reaction":"DIZZINESS"},{"count":39,"reaction":"FATIGUE"},{"count":32,"reaction":"ANXIETY"},{"count":24,"reaction":"ASTHENIA"},{"count":22,"reaction":"ARTHRALGIA"},{"count":22,"reaction":"DYSPNOEA"}],"_approvalHistory":[],"publicationCount":15874,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Estradiol","Prometrium","Micronized progestin","Medroxyprogesterone","Climera"],"phase":"marketed","status":"active","brandName":"Hormone replacement therapy","genericName":"Hormone replacement therapy","companyName":"Faculdade de Medicina do ABC","companyId":"faculdade-de-medicina-do-abc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Hormone replacement therapy supplements deficient endogenous hormones (typically estrogen and/or progesterone) to alleviate symptoms of hormonal imbalance or deficiency. Used for Menopausal vasomotor symptoms (hot flashes, night sweats), Genitourinary atrophy and sexual dysfunction, Osteoporosis prevention in postmenopausal women.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":3,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}