{"id":"hlx04","safety":{"commonSideEffects":[{"rate":"30-40","effect":"Hypertension"},{"rate":"20-30","effect":"Proteinuria"},{"rate":"5-15","effect":"Bleeding"},{"rate":"5-10","effect":"Thromboembolism"},{"rate":"1-2","effect":"Gastrointestinal perforation"},{"rate":"20-30","effect":"Fatigue"},{"rate":"15-25","effect":"Diarrhea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"HLX04 is a bevacizumab biosimilar that targets VEGF, a key signaling molecule responsible for new blood vessel formation in tumors. By neutralizing VEGF, the drug prevents the development of new vasculature that tumors depend on for growth and metastasis. This anti-angiogenic mechanism is used in combination with chemotherapy to treat various solid tumors.","oneSentence":"HLX04 is a monoclonal antibody that binds to and inhibits vascular endothelial growth factor (VEGF), blocking tumor angiogenesis and reducing blood supply to cancer cells.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:44:55.332Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Metastatic colorectal cancer (in combination with chemotherapy)"},{"name":"Non-small cell lung cancer"},{"name":"Metastatic breast cancer"}]},"trialDetails":[{"nctId":"NCT01167712","phase":"PHASE3","title":"Paclitaxel and Carboplatin With or Without Bevacizumab in Treating Patients With Stage II, Stage III, or Stage IV Ovarian Epithelial Cancer, Primary Peritoneal Cancer, or Fallopian Tube Cancer","status":"ACTIVE_NOT_RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2010-09-27","conditions":"Fallopian Tube Endometrioid 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