{"id":"hkt-500-ketoprofen-topical-patch","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin irritation or dermatitis at application site"},{"rate":null,"effect":"Photosensitivity"},{"rate":null,"effect":"Pruritus"}]},"_chembl":{"chemblId":"CHEMBL571","moleculeType":"Small molecule","molecularWeight":"254.29"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"HKT-500 is a transdermal patch formulation of ketoprofen designed to deliver the NSAID directly through the skin to target localized pain and inflammation. By inhibiting COX-1 and COX-2 enzymes, ketoprofen reduces prostaglandin production, which mediates inflammatory responses and pain signaling. The topical patch formulation aims to minimize systemic exposure and associated gastrointestinal and cardiovascular risks associated with oral NSAIDs.","oneSentence":"Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:44:44.209Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Localized musculoskeletal pain and inflammation"},{"name":"Osteoarthritis pain (topical)"}]},"trialDetails":[{"nctId":"NCT00647231","phase":"PHASE2","title":"HKT-500-US12 In Adult Patients With OA Knee Pain","status":"COMPLETED","sponsor":"Hisamitsu Pharmaceutical Co., Inc.","startDate":"2008-03","conditions":"Osteoarthritis, Knee","enrollment":300},{"nctId":"NCT00927641","phase":"PHASE3","title":"HKT-500 in the Treatment of Adult Patients With Ankle Sprain","status":"COMPLETED","sponsor":"Hisamitsu Pharmaceutical Co., Inc.","startDate":"2009-07","conditions":"Ankle Sprain","enrollment":240},{"nctId":"NCT00680472","phase":"PHASE3","title":"HKT-500 in Adult Patients With Shoulder Pain","status":"COMPLETED","sponsor":"Hisamitsu Pharmaceutical Co., Inc.","startDate":"2008-04","conditions":"Pain","enrollment":368},{"nctId":"NCT00792727","phase":"PHASE3","title":"HKT-500 in Adult Patients With Osteoarthritis (OA) Knee Pain","status":"COMPLETED","sponsor":"Hisamitsu Pharmaceutical Co., Inc.","startDate":"2007-09","conditions":"Osteoarthritis of the Knee","enrollment":380},{"nctId":"NCT00680784","phase":"PHASE3","title":"HKT-500 in Adult Patients With Ankle Sprain","status":"COMPLETED","sponsor":"Hisamitsu Pharmaceutical Co., Inc.","startDate":"2008-04","conditions":"Ankle Sprain","enrollment":260}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Ketoprofen Topical Patch"],"phase":"phase_3","status":"active","brandName":"HKT-500 Ketoprofen Topical Patch","genericName":"HKT-500 Ketoprofen Topical Patch","companyName":"Hisamitsu Pharmaceutical Co., Inc.","companyId":"hisamitsu-pharmaceutical-co-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain. Used for Localized musculoskeletal pain and inflammation, Osteoarthritis pain (topical).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}