{"id":"histapyrrodine","rwe":[{"pmid":"2875057","year":"1986","title":"Gas chromatographic determination of histapyrrodine hydrochloride in pharmaceutical preparations.","finding":"","journal":"Journal - Association of Official Analytical Chemists","studyType":"Clinical Study"},{"pmid":"13421807","year":"1957","title":"[Neurosedative action of histapyrrodine; its therapeutic value in anxiety, neurotonic manifestations and states of aggression].","finding":"","journal":"Semaine medicale professionelle et medico-sociale","studyType":"Clinical Study"}],"tags":[{"label":"histapyrrodine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"R06AC02","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"luvistin","offLabel":[],"synonyms":["histapyrrodine hydrochloride","histapyrrodine HCl","histapyrrodine","luvistin"],"timeline":[],"approvals":[],"brandName":"Luvistin","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"histapyrrodine","explanation":"Histamine is a chemical that can cause allergic reactions, itching, and other symptoms. By blocking histamine receptors, Luvistin can help reduce these symptoms. This can be especially helpful for people with conditions like allergies or asthma.","oneSentence":"Luvistin works by blocking histamine receptors in the body.","technicalDetail":"Histapyrrodine acts as a competitive antagonist at histamine receptors, specifically H1 receptors, which are involved in the mediation of allergic responses and other physiological processes."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1376","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=HISTAPYRRODINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:53:22.317802","biosimilars":[],"competitors":[{"drugName":"mepyramine","drugSlug":"mepyramine","fdaApproval":"1973-08-07","relationship":"same-class"},{"drugName":"tripelennamine","drugSlug":"tripelennamine","fdaApproval":"1948-02-19","patentStatus":"Unknown","relationship":"same-class"}],"genericName":"histapyrrodine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"mepyramine","brandName":"mepyramine","genericName":"mepyramine","approvalYear":"1973","relationship":"same-class"},{"drugId":"tripelennamine","brandName":"tripelennamine","genericName":"tripelennamine","approvalYear":"1948","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"006601","UNII":"0FYM61NG4D","CHEBI":"CHEBI:135164","INN_ID":"618","UMLSCUI":"C0628458","ChEMBL_ID":"CHEMBL2105039","KEGG_DRUG":"D07400","DRUGBANK_ID":"DB13479","PUBCHEM_CID":"68122","SECONDARY_CAS_RN":"6113-17-3","MESH_SUPPLEMENTAL_RECORD_UI":"C049920"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":2,"therapeuticAreas":["Respiratory"],"atcClassification":{"source":"DrugCentral","atcCode":"R06AC02","allCodes":["R06AC02","R06AC52"]},"biosimilarFilings":[],"recentPublications":[{"date":"1986 Jul-Aug","pmid":"2875057","title":"Gas chromatographic determination of histapyrrodine hydrochloride in pharmaceutical preparations.","journal":"Journal - Association of Official Analytical Chemists"},{"date":"1957 Jan 30","pmid":"13421807","title":"[Neurosedative action of histapyrrodine; its therapeutic value in anxiety, neurotonic manifestations and states of aggression].","journal":"Semaine medicale professionelle et medico-sociale"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Luvistin, also known as histapyrrodine, is a small molecule drug of unknown target and class. Its commercial status and approved indications are currently unknown. As a histapyrrodine, it is a histamine antagonist, but further information is needed to provide a comprehensive summary. Further research is required to understand its mechanism of action, pharmacokinetics, and safety profile. Its development and ownership history are also unclear.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}